Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

16. Crowe A, Zheng W, Miller J, Pahwa S, Alam K, Fung K, Rubin E, Yin F, Ding K, Yue W. Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism. Pharmaceutical Research. In Press; 36 : 101

17. Farasyn T, Crowe A, Hatley O, Neuhoff S, Alam K, Kanyod J, Lam T, Ding K, Yue W. Preincubation with everolimus and sirolimus reduces organic anion transporting polypeptide (OATP)1B1- and 1B3-mediated transport independently of mTOR kinase inhibition: implication in assessing OATP1B1- and OATP1B3-mediated drug-drug interactions. Journal of Pharmaceutical Sciences. 2019; 108 : 3443

18. Zheng W, Krasinskas A, Yue W, Wang H. OATP1B3 is a novel immunohistochemical marker to discriminate well differentiated hepatocellular carcinoma from its benign hepatocellular mimickers. Modern Pathology. In Press; 32 (S2) : 60

19. Alam K, Crowe A, Wang X, Zhang P, Ding K, Li L, Yue W. Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions. International Journal of Molecular Sciences. 2018; 19 : 855

20. Alam K, Farasyn T, Ding K, Yue W. Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues. Drug Metabolism Letters. 2018

Grants

6. Post-translational regulation of hepatic transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3 by immunosuppressant cyclosporine A: Implication in Transporter-Mediated Drug-Drug Interactions. Misc Non-Federal. Start Date: 2018. End Date: 2019.

7. Post-translational regulation of transporters organic anion transporting polypeptides (OATP) 1B1 and 1B3 by immunosuppressant cyclosporine A: Implication in Transporter-Mediated Drug-Drug Interactions . Misc Non-Federal. Start Date: 2017. End Date: 2018.

8. Administrative amendment of adding human subject research component to current funded R01. NIH. Start Date: 2017. End Date: 2017.

9. Administrative Supplement for Equipment . NIH. Start Date: 2015. End Date: 2017.

10. Function and regulation of OATP1B1 and OATP1B3. NIH. Start Date: 2011. End Date: 2017.

Awards and Honors

1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


2. Shandong University, China. Sunshine scholarship. Date: 1996.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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