Wei Yue, Ph.D.
Associate Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x47828
Fax (405) 271-7505
Office CPB 328
Email wei-yue@ouhsc.edu
Faculty Website https://sites.google.com/view/yuelab
Summary
My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.
Academic Awards
Member, Educators for Excellence
OUHSC
April 2022Publications & Presentations
- 1. Yue W, Farasyn T, Crowe A, Alam K, Garcia-Contreras L, Tu Y, Wang L. Transporters in hepatic and intestinal uptake of orally administered drugs. John Wiley & Sons, Inc. 2024
2. Powell J T, Kayesh R, Ballesteros-Perez A, Alam K, Niyonshuti P, Soderblom E J, ding k, Xu C, Yue W. Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins. Pharmaceutics. 2024; 16 : 63
3. Kayesh R, Tambe V, Xu C, Yue W. Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. Pharmaceutics. 2023; 15 : 1020
4. Brouwer K, Evers R, Hayden E, Hu S, Yanfei Li C, Meyer zu Schwabedissen H, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl J, Stahl S, Yue W. Regulation of Drug Transport Proteins - From Mechanisms to Clinical Impact; A White Paper on Behalf of the ITC. Clinical Pharmacology and Therapeutics . 2022
5. Farasyn T, Xu C, Yue W. Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds. Journal of Pharmacy \& Pharmaceutical Sciences. 2021; 24 : 475--483
Grants
- 1. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.
2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.
3. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.
4. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.
5. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.
Awards and Honors
- 6. Shandong University, China. Sunshine scholarship. Date: 1996.
7. Shandong Agriculture University. Excellent Student Leader . Date: 1994.
8. Shandong Province, China. Excellent Student Leader . Date: 1993.
9. Chinese Ministry of Education. Outstanding Student of China . Date: 1993.
Education
- 1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.
2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.
3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.
4. Degree: MS. Shandong University, China. Date: 1998.
5. Degree: BS. Shandong Agricultural University, China. Date: 1995.
Administrative Assignments
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