H. Anne Pereira, Ph.D.

Prof,David L Boren

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    16. Griffith G L, Kasus-Jacobi A, Lerner M R, Pereira A. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCδ). Investigative ophthalmology & visual science. 2014; 55 : 4886-95

    17. Griffith G L, Russell R A, Kasus-Jacobi A, Pereira A. CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. IOVS. 2013

    18. Pereira H A, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen T T, Pohl J, Wozniak K, Fidel P L. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Medical mycology. 2010; 48 : 263-72

    19. Gordon Y J, Romanowski E G, Shanks R M, Yates K A, Hinsley H, Pereira H A. CAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1. Current eye research. 2009; 34 : 241-9

    20. Pereira H A. Novel therapies based on cationic antimicrobial peptides. Current pharmaceutical biotechnology. 2006; 7 : 229-34

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Grants

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    1. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2018. End Date: 2023.

    2. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

    3. Oklahoma Shared Clinical & Translational Resources. NIH. Start Date: 2013. End Date: 2023.

    4. Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2022.

    5. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

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Awards and Honors

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                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            4. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.