H. Anne Pereira, Ph.D.

Prof,David L Boren

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    11. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira H A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. 2015; 144 : 293-308

    12. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. Histochemistry and cell biology. 2015; 144 : 293-308

    13. Lawrence S M, Eckert J, Makoni M, Pereira H A. Is the Use of Complete Blood Counts with Manual Differentials an Antiquated Method of Determining Neutrophil Composition in Newborns?. Annals of clinical and laboratory science. 2015; 45 : 403-13

    14. Kasus-Jacobi A, Noor-Mohammadi S, Griffith G L, Hinsley H, Mathias L, Pereira A. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties. Journal of leukocyte biology. 2015; 97 : 341-50

    15. Kasus-Jacobi A, Nag O, Awasthi V, Babizhayev M, Pereira A. Investivating carcinine transport and the expression profile of transporter genes in human corneal epithelial cells. Springer. 2015

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Grants

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    1. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2018. End Date: 2023.

    2. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

    3. Oklahoma Shared Clinical & Translational Resources. NIH. Start Date: 2013. End Date: 2023.

    4. Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2022.

    5. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

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Awards and Honors

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                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            4. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.