H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    1. Hughes O, Bentley A R, Breeze C E, Aguet F, Xu X, Nadkarni G, Sun Q, Lin B M, Gilliland T, Meyer M C, Du J, Raffield L M, Kramer H, Morton R W, Gouveia M H, Atkinson E G, Valladares-Salgado A, Wacher-Rodarte N, Dueker N D, Guo X, Hai Y, Adeyemo A, Best L G, Cai J, Chen G, Chong M, Doumatey A, Eales J, Goodarzi M O, Ipp E, Irvin M R, Jiang M, Jones A C, Kooperberg C, Krieger J E, Lange E M, Lanktree M B, Lash J P, Lotufo P A, Ha My V T, Peralta-Romero J, Qi L, Raffel L J, Rich S S, Rodriquez E J, Tarazona-Santos E, Taylor K D, Umans J G, Wen J, Young B A, Yu Z, Zhang Y, Ida Chen Y D, Rundek T, Rotter J I, Cruz M, Fornage M, Lima-Costa M F, Pereira A, Paré G, Natarajan P, Cole S A, Carson A P, Lange L A, Li Y, Perez-Stable E J, Do R, Charchar F J, Tomaszewski M, Mychaleckyj J C, Rotimi C, Morris A P, Franceschini N. Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. Cell genomics. 2023

    2. Kasus-Jacobi A, Washburn J L, Laurence R B, Pereira A. Selecting Multitarget Peptides for Alzheimer's Disease. Biomolecules. 2022; 12 : 1386

    3. Kasus-Jacobi A, Washburn J, Land C, Pereira A. Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity. Current Alzheimer Research. 2021; 18 : 414-427

    4. Kasus-Jacobi A, Land C, Stock A, Washburn J, Pereira A. Antimicrobial peptides derived from the immune defense protein CAP37 inhibit TLR4 activation by S100A9. Investigative Ophthalmology & Visual Science/Association for Research in Vision and Ophthalmology. 2020

    5. Stock A J, Kasus-Jacobi A, Pereira A. The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease. Journal of neuroinflammation. 2018; 15 : 240

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Grants

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    16. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.

    17. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.

    18. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.

    19. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.

    20. Role of CAP37 in Neuroinflammation: Friend or Foe?. State Agency. Start Date: 2012. End Date: 2015.

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Awards and Honors

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                                                                                            6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.  

                                                                                            7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.  

                                                                                            8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.  

                                                                                            9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.  

                                                                                            10. Department of Pathology. Fred G Silva Research Award. Date: 1999.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.