H. Anne Pereira, Ph.D.

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Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

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Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

Patents

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Publications & Presentations

41. Pereira H A, Spitznagel J K, Winton E F, Shafer W M, Martin L E, Guzman G S, Pohl J, Scott R W, Marra M N, Kinkade, Jr J M. The ontogeny of a 57-Kd cationic antimicrobial protein of human polymorphonuclear leukocytes: localization to a novel granule population. Blood. 1990; 76 : 825-34

42. Pereira H A, Shafer W M, Pohl J, Martin L E, Spitznagel J K. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. The Journal of clinical investigation. 1990; 85 : 1468-76

43. Pereira H A, Spitznagel J K, Pohl J, Wilson D E, Morgan J, Palings I, Larrick J W. CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. Life sciences. 1990; 46 : 189-96

44. Pereira H A, Martin L E, Spitznagel J K. Quantitation of a cationic antimicrobial granule protein of human polymorphonuclear leukocytes by ELISA. Journal of immunological methods. 1989; 117 : 115-20

45. Spitznagel J K, Pereira H A, Martin L E, Guzman G S, Shafer W M. A monoclonal antibody that inhibits the antimicrobial action of a 57 KD cationic protein of human polymorphonuclear leukocytes. Journal of immunology (Baltimore, Md. : 1950). 1987; 139 : 1291-6

Grants

6. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

7. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.

8. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.

9. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

10. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.

Awards and Honors

16. American Lung Association. American Lung Association Research Award. Date: 1990.


17. Gordon Research Conference on Phagocytes, New Hampshire. Travel Scholarship. Date: 1987.


18. University of Melbourne, Australia. BSc (Honours) First Class Honours and First Place. Date: 1977.


19. Commonwealth of Australia. Commonwealth Postgraduate Research Award. Date: 1977.

Education

1. Degree: Ph D. University of Melbourne. Date: 1982.


2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.


3. Degree: BS. University of Melbourne. Date: 1975.

Administrative Assignments

1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
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2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.
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