Shanjana Awasthi, Ph.D.

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Summary

Research in my lab is focused on developing immunotherapeutics and vaccines by harnessing our body's natural host defense mechanisms. Our research efforts have been focused on developing TLR4-interacting surfactant protein-A-derived peptides and dendritic cell-based vaccine approaches. We are interested in investigating the mechanisms of action and efficacy of these approaches using structural, computational, physicochemical, and immunological tools and methods, and in vitro and in animal models of infection, inflammation and cancer.

Certifications & Licenses

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Publications & Presentations

1. Awasthi S, Singh B, Ramani V, Godbole N M, King C. Involvement of endoplasmic reticulum- and histone-proteins in immunomodulation by TLR4-interacting SPA4 peptide against Escherichia coli. . Infection and Immunity. 2023; 91 : e0031123

2. Chowdhury A, Rodgers K, Godbole N M, Awasthi S. Stability and structure-activity relation of SPA4 peptide under ambient and stressed conditions of lung injury. . RSC Advances. 2023; 13 : 18864-18877

3. Godbole N, Awasthi S. SPA4 peptide suppresses the lipopolysaccharide (LPS)-stimulated lactate secretion in lung epithelial cells through modulation of Toll-like receptor-4 (TLR4). J Immunol. 2023; 210 (1. Supplement) Meeting abstracts : 160.17

4. Chowdhury A, Godbole N, Awasthi S. SPA4 peptide treatment reduces the lipopolysaccharide (LPS)-stimulated CXCL1/KC and lactate in primary mouse lung alveolar epithelial cells. Am J Respir Crit Care Med. 2023; 207: Meeting abstracts : A1724

5. Chowdhury A A, Godbole N M, Chataut N, Kosanke S, Rodgers K, Awasthi S. Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury. Physiological reports. 2022; 10 : e15353

Grants

6. Modulation of host defense by SP-A-TLR4 interaction. American Heart Association. Start Date: 2011. End Date: 2013.

7. Host immune response to Enterococcus faecalis biofilms. NIH. Start Date: 2010. End Date: 2012.

8. Interaction between baboon lung surfactant Protein-A and Toll-like Receptor 4. Non-federal. Start Date: 2008. End Date: 2010.

9. Evaluation of a vaccine for Coccidioides in a mouse model. Non-federal. Start Date: 2007. End Date: 2010.

10. Evaluation of freeze-dried platelets in a rabbit model . Non-federal. Start Date: 2007. End Date: 2010.

Awards and Honors

11. Clinical and Laboratory Standards Institute. Certificate of Appreciation. Date: 2013.


12. Tech Connect Ventures in partnership with Blue Origin and Sierra Space. Finalist of Reef Starter Innovation Challenge. Date: 2022.

Education

1. Degree: Post-Baccalaureate Categorical certificate in Clinical Microbiology. University of Texas Health Sciences Center at San Antonio. Date: 2006.


2. Degree: Ph D. Sanjay Gandhi Post Graduate Institute of Medical Sciences. Date: 1995.


3. Degree: MS. Indian Institute of Technology (IIT). Date: 1990.


4. Degree: BS. MKP College, HNM Garhwal University. Date: 1988.

Administrative Assignments

no results

External Connections and Partnerships

1. Type: Funding. Org: Oklahoma State University (year 2013- year 2017). City: Stillwater. State: Oklahoma. NIH-supported COBRE program in Respiratory and Infectious Diseases. Date: 2013.


2. Type: Funding. Org: University of Oklahoma (year 2013- year 2014). City: Norman. State: Oklahoma. NIH-supported COBRE program in Structural Biology. Date: 2013.