Wei Yue, Ph.D.

Associate Professor

Pharmaceutical Sciences

Phone (405) 271-6593 x47828

Fax (405) 271-7505

Office CPB 328

Email wei-yue@ouhsc.edu

Faculty Website https://sites.google.com/view/yuelab


Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.



Academic Awards

Member, Educators for Excellence

OUHSC

April 2022


Publications & Presentations

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    16. Crowe A, Zheng W, Miller J, Pahwa S, Alam K, Fung K, Rubin E, Yin F, Ding K, Yue W. Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism. Pharmaceutical Research. In Press; 36 : 101

    17. Farasyn T, Crowe A, Hatley O, Neuhoff S, Alam K, Kanyod J, Lam T, Ding K, Yue W. Preincubation with everolimus and sirolimus reduces organic anion transporting polypeptide (OATP)1B1- and 1B3-mediated transport independently of mTOR kinase inhibition: implication in assessing OATP1B1- and OATP1B3-mediated drug-drug interactions. Journal of Pharmaceutical Sciences. 2019; 108 : 3443

    18. Zheng W, Krasinskas A, Yue W, Wang H. OATP1B3 is a novel immunohistochemical marker to discriminate well differentiated hepatocellular carcinoma from its benign hepatocellular mimickers. Modern Pathology. In Press; 32 (S2) : 60

    19. Alam K, Crowe A, Wang X, Zhang P, Ding K, Li L, Yue W. Regulation of organic anion transporting polypeptides (OATP) 1B1- and OATP1B3-mediated transport: an updated review in the context of OATP-mediated drug-drug interactions. International Journal of Molecular Sciences. 2018; 19 : 855

    20. Alam K, Farasyn T, Ding K, Yue W. Characterization of liver- and cancer-type-organic anion transporting polypeptide (OATP) 1B3 messenger RNA expression in normal and cancerous human tissues. Drug Metabolism Letters. 2018

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Grants

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    1. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.

    2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.

    3. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.

    4. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.

    5. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.

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Awards and Honors

                                                                                            1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.  

                                                                                            2. Shandong University, China. Sunshine scholarship. Date: 1996.  




Education

                                                                                            1.  Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.  

                                                                                            2.  Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.  

                                                                                            3.  Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.  

                                                                                            4.  Degree: MS. Shandong University, China. Date: 1998.  

                                                                                            5.  Degree: BS. Shandong Agricultural University, China. Date: 1995.