Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

21. Alam K, Farasyn T, Crowe A, Ding K, Yue W. Treatment with Proteasome Inhibitor Bortezomib Decreases Organic Anion Transporting Polypeptide (OATP) 1B3-Mediated Transport in a Substrate-Dependent Manner. Public Library of Science ONE. 2017; 12 : e0186924

22. Pahwa S, Alam K, Crowe A, Farasyn T, Sibylle N, Hatley O, Ding K, Yue W. Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport. Journal of Pharmaceutical Sciences. 2017; 106 : 2123

23. Alam K, Pahwa S, Wang X, Zhang P, Ding K, Abuznait A, Li L, Yue W. Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Molecular Pharmaceutics. 2016; 13 : 839–851

24. Farasyn T. Rapid down-regulation of organic anion transporting polypeptide (OATP) 1B3 transport function by phosphorylation modulators in sandwich-cultured hepatocytes: A novel mechanism of OATP1B3 inhibition. Drug Metabolism Reviews. 2015; 47(S1) : 259

25. Powell J, Farasyn T, Kock K, Meng X, Pahwa S, Brouwer K K, Yue W. Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metabolism and Disposition. 2014; 42 : 1964-1970

Grants

1. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.

2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.

3. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.

4. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.

5. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.

Awards and Honors

1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


2. Shandong University, China. Sunshine scholarship. Date: 1996.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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