Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

26. Powell J, Farasyn T, Kock K, Meng X, Pahwa S, Brouwer K K, Yue W. Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metabolism and Disposition. 2014; 42 : 1964-1970

27. Yang K, Pfeifer N D, Hardwick R N, Yue W, Stewart P W, Brouwer K L. An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR^- Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown. Molecular pharmaceutics. 2014

28. Bheda A, Yue W, Gullapalli A, Shackelford J, Pagano J S. PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells. Leukemia & lymphoma. 2011; 52 : 1336-47

29. Marion T L, Perry C H, St Claire, 3rd R L, Yue W, Brouwer K L. Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2011; 120 : 371-80

30. Yue W, Lee J K, Abe K, Sugiyama Y, Brouwer K L. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats. Drug metabolism and disposition: the biological fate of chemicals. 2011; 39 : 441-7

Grants

1. Equipment supplement award-Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2024. End Date: 2026.

2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.

3. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.

4. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.

5. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.

Awards and Honors

1. OUHSC. Regents’ Award for Superior Teaching. Date: 2024.


2. ASPET. ASPET IDEA Faculty Scholars. Date: 2024.


3. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


4. OUHSC. Member of Educators for Excellence of OUHSC. Date: 2022.


5. OUHSC. Provost’s Teaching Award-Early Career Faculty . Date: 2021.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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