Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

36. Yue W, Abe K, Brouwer K L. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Molecular pharmaceutics. 2009; 6 : 134-43

37. Abe K, Bridges A S, Yue W, Brouwer K L. In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance. The Journal of pharmacology and experimental therapeutics. 2008; 326 : 983-90

38. Yue W, Shackelford J, Pagano J S. cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis. Journal of virology. 2006; 80 : 2045-50

39. Yue W, Gershburg E, Pagano J S. Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter. Journal of virology. 2005; 79 : 5880-5

40. Jin Y L, Yue W, Shi G X, Liu Y, Zhao F T, Zhu L P. Inhibition of 6A8 alpha-mannosidase gene expression resulted in telomere length shortening in nasopharyngeal carcinoma cell CNE-2L2. Cancer letters. 2005; 218 : 229-34

Grants

1. Regulation of organic cation transporter 1 transport function by lysine deacetylase 6: implications in drug-nutrient interactions. Non-federal. Start Date: 2025. End Date: 2026.

2. Equipment supplement award-Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2024. End Date: 2026.

3. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.

4. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.

5. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.

Awards and Honors

1. ASPET. ASPET Faculty Scholars. Date: 2025.


2. OUHSC. Regents’ Award for Superior Teaching. Date: 2024.


3. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


4. OUHSC. Member of Educators for Excellence of OUHSC. Date: 2022.


5. OUHSC. Provost’s Teaching Award-Early Career Faculty . Date: 2021.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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