Vibhuti Agrahari, Ph.D.
Prof,Asst
Pharmaceutical Sciences
Phone 405-271-6751 x47244
Fax 405-271-7505
Office COP200
Email Vibhuti-Agrahari@ou.edu
Summary
My research focuses on long-term drug delivery by designing innovative systems such as nanocarriers, micelles, and hydrogels using biomaterials. The research activities include rationale design, optimization, and evaluation of the nanoformulations for local, targeted and sustained delivery of biotherapeutic and small molecule drugs using stimuli-responsive polymers, natural polymers, block- and random- copolymers, etc. The ultimate goal of my research laboratory is to develop biomaterials that can provide selective, controlled, non-toxic, biodegradable, and stimuli-responsive platforms to target therapeutic agents to the sites of ocular and inner ear diseases. My laboratory is specialized in the area of (a) sustained delivery of protein/antibodies for the back of eye diseases. (b) non-invasive treatment, and prevention of vision loss due to ocular injuries. (c) next-generation therapeutics for anterior segment ocular diseases (d) nanotherapeutic approaches to provide a prophylactic cure for Chemotherapeutic-Induced Ototoxicity (CIO).
Grants
New Investigator Grant: "Bio-responsive NanoSensoGel for Prevention of Cisplatin-induced Ototoxity and Hearing Loss"
Presbyterian Health Foundation
07/01/2021 - 06/30/2022CFAR Grant: "ROS-responsive NanoSensoGel for Prevention of Cistplatin-Induced Ototoxicity and Hearing Loss"
Capita Foundation
11/01/2021 - 12/31/2022Publications & Presentations
- 36. Agrahari V, Agrahari V, Mitra A K. Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities. THERAPEUTIC DELIVERY. 2016; 7 : 257-278
37. Yang X, Shah S J, Wang Z, Agrahari V, Pal D, Mitra A K. Nanoparticle-based topical ophthalmic formulation for sustained release of stereoisomeric dipeptide prodrugs of ganciclovir. DRUG DELIVERY. 2016; 23 : 2399-2409
38. Yang X, Trinh H M, Agrahari V, Sheng Y, Pal D, Mitra A K. Nanoparticle-Based Topical Ophthalmic Gel Formulation for Sustained Release of Hydrocortisone Butyrate. AAPS PHARMSCITECH. 2016; 17 : 294-306
39. Patel S P, Vaishya R, Patel A, Agrahari V, Pal D, Mitra A k. Optimization of novel pentablock copolymer based composite formulation for sustained delivery of peptide/protein in the treatment of ocular diseases. JOURNAL OF MICROENCAPSULATION. 2016; 33 : 103-113
40. Mitra A K, Patel S, Vaishya R, Agrahari V. Biodegradable and Injectable Thermosensitive Pentablock Copolymers Hydrogels for Sustained Delivery of Proteins for Posterior Segment Ocular Diseases. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2015; 56
Grants
- 1. Bio-responsive Nano-SensoGel for Prevention of Chemotherapy-Induced Ototoxicity and Hearing Loss . Non-federal. Start Date: 2021. End Date: 2022.
Awards and Honors
- 6. National Biotechnology Conference, AAPS. Biotechnology Graduate Student Symposium Award,. Date: 2016.
7. University of Missouri-Kansas City Preparing Future Faculty Program Scholar Award. Date: 2016.
8. American Association of Pharmaceutical Scientists. Quality by Design and Product Performance Graduate Student Award. Date: 2016.
9. University of Missouri-Kansas City Ronald MacQuarrie Fellowship. Date: 2016.
10. University of Missouri System. Graduate Student Professional Development and Leadership Program. Date: 2015.
Education
- 1. Degree: Ph D. University of Missouri- Kansas City. Date: 2017.
2. Degree: M. Pharm.. Shri G.S. Institute of Technology & Science, India . Date: 2008.
3. Degree: B. Pharm. Shri G.S. Institute of Technology & Science, India . Date: 2005.
Administrative Assignments
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