Vibhuti Agrahari, Ph.D.
My research focuses on long-term drug delivery by designing innovative systems such as nanocarriers, micelles, and hydrogels using biomaterials. The research activities include rationale design, optimization, and evaluation of the nanoformulations for local, targeted and sustained delivery of biotherapeutic and small molecule drugs using stimuli-responsive polymers, natural polymers, block- and random- copolymers, etc. The ultimate goal of my research laboratory is to develop biomaterials that can provide selective, controlled, non-toxic, biodegradable, and stimuli-responsive platforms to target therapeutic agents to the sites of ocular and inner ear diseases. My laboratory is specialized in the area of (a) sustained delivery of protein/antibodies for the back of eye diseases. (b) non-invasive treatment, and prevention of vision loss due to ocular injuries. (c) next-generation therapeutics for anterior segment ocular diseases (d) nanotherapeutic approaches to provide a prophylactic cure for Chemotherapeutic-Induced Ototoxicity (CIO).
New Investigator Grant: "Bio-responsive NanoSensoGel for Prevention of Cisplatin-induced Ototoxity and Hearing Loss"
Presbyterian Health Foundation07/01/2021 - 06/30/2022
CFAR Grant: "ROS-responsive NanoSensoGel for Prevention of Cistplatin-Induced Ototoxicity and Hearing Loss"
Capita Foundation11/01/2021 - 12/31/2022
Publications & Presentations
- 1. Agrahari V, Chauhan H. Polyphenols against infectious diseases: Controlled release nano-formulations. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2021; 161 : 66-79
2. Agrahari V, Agrahari V, Chou M, Chew C H, Noll J, Burnouf T. Intelligent micro-/nanorobots as drug and cell carrier devices for biomedical therapeutic advancement: Promising development opportunities and translational challenges. BIOMATERIALS. 2020; 260
3. Agrahari V, Agrahari V, Burnouf P, Chew C H, Burnouf T. Extracellular Microvesicles as New Industrial Therapeutic Frontiers. TRENDS IN BIOTECHNOLOGY. 2019; 37 : 707-729
4. Burnouf T, Agrahari V, Agrahari V. Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation. INTERNATIONAL JOURNAL OF NANOMEDICINE. 2019; 14 : 8847-8859
5. Li G, Lee C, Agrahari V, Wang K, Navarro I, Sherwood J M, Crews K, Farsiu S, Gonzalez P, Lin C, Mitra A K, Ethier C R, Stamer W D. In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019; 116 : 1714-1722
- 1. Bio-responsive Nano-SensoGel for Prevention of Chemotherapy-Induced Ototoxicity and Hearing Loss . Non-federal. Start Date: 2021. End Date: 2022.
Awards and Honors
- 1. Shenandoah University. Bernard J. Dunn, Jr. Faculty Research Award. Date: 2018.
2. Shenandoah University. Single Discipline Faculty Development Award. Date: 2018.
3. Society for Laboratory Automation Science. Tony B. Academic Travel Award. Date: 2017.
4. National Biotechnology Conference, AAPS. Biotechnology Graduate Student Symposium Award,. Date: 2016.
5. American Association of Pharmaceutical Scientists. Quality by Design and Product Performance Graduate Student Award. Date: 2016.
- 1. Degree: Ph D. University of Missouri- Kansas City. Date: 2017.
2. Degree: M. Pharm.. Shri G.S. Institute of Technology & Science, India . Date: 2008.
3. Degree: B. Pharm. Shri G.S. Institute of Technology & Science, India . Date: 2005.