Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

16. Liu Q, Keyesh R, Farasyn T, Li Y, Vu N, Kupiec T, Yue W. A sensitive quantification method of unbound vemurafenib in human plasma using equilibrium dialysis followed by ultra-performance liquid chromatography coupled to a tandem mass spectrometry. PharmSci 360-AAPS Annual Meeting. 2019

17. Kayesh R, Farasyn T, Crowe A, Liu Q, Pahwa S, Alam K, Ding K, Neuhoff S, Hatley O, Yue W. Assessing OATP1B1- and OATP1B3-mediated drug-drug interaction potential of vemurafenib using static and physiologically based pharmacokinetic models. PharmSci 360-AAPS Annual Meeting. 2019

18. Wang L, Yue W, Hu M. Cellular uptake kinetic studies of Wogonoside, Luteolin 3’-glucuronide and apigenin 7-glucuronide in OATP1B1, 1B3 and 2B1 overexpressed HEK-293 cell lines. PharmSci 360-AAPS Annual Meeting. 2019

19. Crowe A, Miller J, Yue W. Genotyping of the OATP1B1 c. 521 T>C polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens: an optimized protocol. Bio-Protocol. 2019; 9

20. Crowe A, Zheng W, Miller J, Pahwa S, Alam K, Fung K, Rubin E, Yin F, Ding K, Yue W. Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C polymorphism. Pharmaceutical Research. In Press; 36 : 101

Grants

11. Administrative Supplement for Equipment . NIH. Start Date: 2015. End Date: 2017.

12. Function and regulation of OATP1B1 and OATP1B3. NIH. Start Date: 2011. End Date: 2017.

Awards and Honors

1. ASPET. ASPET Faculty Scholars. Date: 2025.


2. OUHSC. Regents’ Award for Superior Teaching. Date: 2024.


3. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


4. OUHSC. Member of Educators for Excellence of OUHSC. Date: 2022.


5. OUHSC. Provost’s Teaching Award-Early Career Faculty . Date: 2021.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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