Randle Gallucci, Ph.D.

Professor/Director of Graduate Programs

Pharmaceutical Sciences

Phone (405) 271-6593 x47188

Fax (405) 271-7505

Office CPB 333

Email randy-gallucci@ouhsc.edu

Summary

The research in my laboratory primarily focuses on the positive and negative roles that inflammatory cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two-fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of techniques including, Luminex Multiplex assay, flow cytometry, and RNAseq. Therapeutic studies have involved the reconstitution of wound healing in models of chronic wounds such diabetic and specific gene knockout mice.



Publications & Presentations

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    16. Luckett-Chastain L R, Smith M L, Mickle B M, Ihnat M, Gallucci R. Interleukin (IL)-6 modulates transforming growth factor -β receptor II (TGF-βRII) function in epidermal keratinocytes. Experimental Dermatology. 2017; 26 : 697-704

    17. Lee E G, Mickle-Kawar B M, Gallucci R. IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. Journal of immunotoxicology. 2013; 10 : 192-200

    18. Lee E G, Mickle-Kawar B M, Reinke L A, Gallucci R. Estrogen suppresses heptatic IκB expression during short-term alcohol exposure. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 2012; 61 : 1053-61

    19. Luckett-Chastain L R, Ihnat M, Mickle-Kawar B M, Gallucci R. SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2012; 32 : 207-15

    20. Van Amburgh J, Surratt C K, Green J S, Gallucci R, Colbert J, Zatopek S L, Blouin R A. Succession planning in US pharmacy schools. American journal of pharmaceutical education. 2010; 74

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Grants

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    1. The role of CCR3 in keratinocyte function. Misc Non-Federal. Start Date: 2024. End Date: 2025.

    2. The Macrophage/Tuft Cell Axis in SUCNR1 Sensing of Extracellular Succinate in Neonatal Intestinal Inflammation. NIAID. Start Date: 2023. End Date: 2025.

    3. Experimental and computational studies to identify optimal conditions for immune-cytotoxic combination therapy. State Agency. Start Date: 2022. End Date: 2024.

    4. Nephrotoxic mechanisms of low-rank coal (lignite) leachates in drinking wate. NIH. Start Date: 2020. End Date: 2023.

    5. Effect of end-toxemia on colchicine plasma levels. ACCP. Start Date: 2022. End Date: 2022.

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Awards and Honors

                                                                                            1. OUHSC. OUHSC President's Associates Professorship. Date: 2017.  

                                                                                            2. OUHSC. Provost's Junior Faculty Research Award. Date: 2005.  




                        		 
                                                                                  
                        
                        
                      
                  
 
                
     
                
                 	                                        
                    
                                            	                           
                                                
                                                                                                                      
Education
 
                               
                                                            
                        
                                                                                            1.  Degree: Ph D. Washington State University. Date: 1995.  

                                                                                            2.  Degree: BA. Central Washington University. Date: 1987.  




                        		 
                                                                                  
                        
                                                                               
 
                   
 
                
     
                
                 	                                        
                    
                                            	                           
                                                
                                                                                                                                                                               
Administrative Assignments

                                  
                                                           
                        
                                                
     1. Role: Director. Scope: College. Description: Oversee the graduate programs within the College of Pharmacy. Date: 2023.