Randle Gallucci, Ph.D.
The research in my laboratory primarily focuses on the positive and negative roles that inflammatory cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two-fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of techniques including, Luminex Multiplex assay, flow cytometry, and RNAseq. Therapeutic studies have involved the reconstitution of wound healing in models of chronic wounds such diabetic and specific gene knockout mice.
Education & Experience
Ph.D. in Pharmacology/Toxicology
Washington State University
B.A. in Chemistry/Biology
Central Washington University
Honors & Awards
OUHSC Provost's Junio Faculty Research Award
Publications & Presentations
- Yucesoy B, Gallucci R. Systems Biology in Immunotoxicology. Elsevier Ltd. 2018 : 559-581
- Gallucci R. Transforming growth factor-β and psoriasis: a new link. British journal of Dermatology. 2017; 177 : 1480-1481
- Luckett-Chastain L R, Smith M L, Mickle B M, Ihnat M, Gallucci R. Interleukin (IL)-6 modulates transforming growth factor -β receptor II (TGF-βRII) function in epidermal keratinocytes. Experimental Dermatology. 2017; 26 : 697-704
- Lee E G, Bastian A, Luckett-Chastain L R, Kawar B M, Gallucci R. Interleukin 6 receptor function in skin and isolated keratinocytes is modulated by hyperglycemia . Inflammation Research/Springer. In Press
- Lee E G, Mickle-Kawar B M, Gallucci R. IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. Journal of immunotoxicology. 2013; 10 : 192-200