Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

1. Aditya V, Tambe V, Yue W. Development of a Novel Automated Workflow in Fiji ImageJ for Batch Analysis of Confocal Imaging Data to Quantify Protein Colocalization Using Manders Coefficient. Bio Protocol. 2025; 15 : e5285

2. Tambe V, Soderblom E J, Kayesh R, Aditya V, Xu C, Yue W. Regulation of OATP1B1 Transport Function by Concurrent Phosphorylation and Lysine-Acetylation-A Novel Post-Translational Regulation Mechanism. Molecular Pharmacology. 2025; 107 : 100007

3. Niyonshuti P, Yue W. Assessing the Inductive Effect of the Histone Deacetylase Inhibitor Romidepsin on OATP1B1 Expression and Transport Function . The Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3). doi: 10.1016/j.jpet.2025.103505. In Press

4. Yue W, Farasyn T, Crowe A, Alam K, Garcia-Contreras L, Tu Y, Wang L. Transporters in hepatic and intestinal uptake of orally administered drugs. John Wiley & Sons, Inc. 2024

5. Powell J T, Kayesh R, Ballesteros-Perez A, Alam K, Niyonshuti P, Soderblom E J, ding k, Xu C, Yue W. Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins. Pharmaceutics. 2023; 16 : 63

Grants

11. Administrative Supplement for Equipment . NIH. Start Date: 2015. End Date: 2017.

12. Function and regulation of OATP1B1 and OATP1B3. NIH. Start Date: 2011. End Date: 2017.

Awards and Honors

6. OUHSC. Tenure . Date: 2020.


7. Shandong University, China. Sunshine scholarship. Date: 1996.


8. Shandong Agriculture University. Excellent Student Leader . Date: 1994.


9. Shandong Province, China. Excellent Student Leader . Date: 1993.


10. Chinese Ministry of Education. Outstanding Student of China . Date: 1993.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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