Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

41. Yue W, Davenport M G, Shackelford J, Pagano J S. Mitosis-specific hyperphosphorylation of Epstein-Barr virus nuclear antigen 2 suppresses its function. Journal of virology. 2004; 78 : 3542-52

42. Yue W, Jin Y L, Shi G X, Liu Y, Gao Y, Zhao F T, Zhu L P. Suppression of 6A8 alpha-mannosidase gene expression reduced the potentiality of growth and metastasis of human nasopharyngeal carcinoma. International journal of cancer. Journal international du cancer. 2004; 108 : 189-95

43. Yue W, Zhan S B, Gao Y, Shi G X, Liu Y, Zhao F T, Zhu L P. [Molecular mechanism of metastasis inhibition of nasopharyngeal carcinoma cell CNE-2L2 induced by reduction of 6A8 alpha-mannosidase expression]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2003; 25 : 655-8

44. Yue W, Zhao F T, Shi G X, Liu Y, Zhu L P. [Inhibition of 6A8 alpha-manosidase expression induces decrease of adhesion to laminin and reduction of lamellipodia of human nasopharyngeal carcinoma cell CNE-2L2]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2003; 25 : 316-9

45. Yue W, Xia G, Zhi D, Chen H. Transfer of salt tolerance from Aeleuropus littorulis sinensis to wheat (Triticum aestivum L.) via asymmetric somatic hybridization. Plant Science. 2001; 161 : 259

Grants

11. Administrative Supplement for Equipment . NIH. Start Date: 2015. End Date: 2017.

12. Function and regulation of OATP1B1 and OATP1B3. NIH. Start Date: 2011. End Date: 2017.

Awards and Honors

1. ASPET. ASPET Faculty Scholars. Date: 2025.


2. OUHSC. Regents’ Award for Superior Teaching. Date: 2024.


3. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


4. OUHSC. Member of Educators for Excellence of OUHSC. Date: 2022.


5. OUHSC. Provost’s Teaching Award-Early Career Faculty . Date: 2021.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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