Wei Yue, Ph.D.

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Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

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Publications & Presentations

26. Alam K, Pahwa S, Wang X, Zhang P, Ding K, Abuznait A, Li L, Yue W. Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Molecular Pharmaceutics. 2016; 13 : 839–851

27. Farasyn T. Rapid down-regulation of organic anion transporting polypeptide (OATP) 1B3 transport function by phosphorylation modulators in sandwich-cultured hepatocytes: A novel mechanism of OATP1B3 inhibition. Drug Metabolism Reviews. 2015; 47(S1) : 259

28. Powell J, Farasyn T, Kock K, Meng X, Pahwa S, Brouwer K K, Yue W. Novel mechanism of impaired function of organic anion transporting polypeptide (OATP) 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metabolism and Disposition. 2014; 42 : 1964-1970

29. Yang K, Pfeifer N D, Hardwick R N, Yue W, Stewart P W, Brouwer K L. An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR^- Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown. Molecular pharmaceutics. 2014

30. Bheda A, Yue W, Gullapalli A, Shackelford J, Pagano J S. PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells. Leukemia & lymphoma. 2011; 52 : 1336-47

Grants

6. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.

7. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.

8. Post-translational regulation of hepatic transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3 by immunosuppressant cyclosporine A: Implication in Transporter-Mediated Drug-Drug Interactions. Misc Non-Federal. Start Date: 2018. End Date: 2019.

9. Post-translational regulation of transporters organic anion transporting polypeptides (OATP) 1B1 and 1B3 by immunosuppressant cyclosporine A: Implication in Transporter-Mediated Drug-Drug Interactions . Misc Non-Federal. Start Date: 2017. End Date: 2018.

10. Administrative amendment of adding human subject research component to current funded R01. NIH. Start Date: 2017. End Date: 2017.

Awards and Honors

1. ASPET. ASPET Faculty Scholars. Date: 2025.


2. OUHSC. Regents’ Award for Superior Teaching. Date: 2024.


3. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


4. OUHSC. Member of Educators for Excellence of OUHSC. Date: 2022.


5. OUHSC. Provost’s Teaching Award-Early Career Faculty . Date: 2021.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

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