Vibhuti Agrahari, Ph.D.
Assistant Professor
Pharmaceutical Sciences
Phone 405-271-6751 x47244
Fax 405-271-7505
Office CPB 325
Summary
My research focuses on long-term drug delivery by designing innovative systems such as nanocarriers, micelles, and hydrogels using biomaterials. The research activities include rationale design, optimization, and evaluation of the nanoformulations for local, targeted and sustained delivery of biotherapeutic and small molecule drugs using stimuli-responsive polymers, natural polymers, block- and random- copolymers, etc. The ultimate goal of my research laboratory is to develop biomaterials that can provide selective, controlled, non-toxic, biodegradable, and stimuli-responsive platforms to target therapeutic agents to the sites of ocular and inner ear diseases. My laboratory is specialized in the area of (a) sustained delivery of protein/antibodies for the back of eye diseases. (b) non-invasive treatment, and prevention of vision loss due to ocular injuries. (c) next-generation therapeutics for anterior segment ocular diseases (d) nanotherapeutic approaches to provide a prophylactic cure for Chemotherapeutic-Induced Ototoxicity (CIO).
Grants
New Investigator Grant: "Bio-responsive NanoSensoGel for Prevention of Cisplatin-induced Ototoxity and Hearing Loss"
Presbyterian Health Foundation
07/01/2021 - 06/30/2022CFAR Grant: "ROS-responsive NanoSensoGel for Prevention of Cistplatin-Induced Ototoxicity and Hearing Loss"
Capita Foundation
11/01/2021 - 12/31/2022Publications & Presentations
- 31. Mitra A K, Patel S, Vaishya R, Agrahari V. Biodegradable and Injectable Thermosensitive Pentablock Copolymers Hydrogels for Sustained Delivery of Proteins for Posterior Segment Ocular Diseases. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2015; 56
32. Agrahari V, Joseph M, Patel S, Vaishya R, Mitra A K. Development, optimization and evaluation of biological activity of tailor-made penta block copolymer based composite formulation for sustained delivery of protein therapeutics. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2015; 56
33. Mitra A K, Agrahari V, Mandal A, Cholkar K, Natarajan C, Shah S, Joseph M, Trinh H M, Vaishya R, Yang X, Hao Y, Khurana V, Pal D. Novel delivery approaches for cancer therapeutics. JOURNAL OF CONTROLLED RELEASE. 2015; 219 : 248-268
34. Barot M, Gokulgandhi M R, Agrahari V, Pal D, Mitra A K. Monocarboxylate transporter mediated uptake of moxifloxacin on human retinal pigmented epithelium cells. JOURNAL OF PHARMACY AND PHARMACOLOGY. 2014; 66 : 574-583
35. Agrahari V, Patel S P, Mitra A K. Novel Pentablock Copolymer Based Nanoformulations for Sustained Ocular Delivery of Protein Therapeutics. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2014; 55
Grants
- 1. Bio-responsive Nano-SensoGel for Prevention of Chemotherapy-Induced Ototoxicity and Hearing Loss . Non-federal. Start Date: 2021. End Date: 2022.
Awards and Honors
- 6. National Biotechnology Conference, AAPS. Biotechnology Graduate Student Symposium Award,. Date: 2016.
7. American Association of Pharmaceutical Scientists. Quality by Design and Product Performance Graduate Student Award. Date: 2016.
8. American Association of Pharmaceutical Scientists. Ocular Drug Delivery Disposition Focus Group (ODDDFG) Award. Date: 2015.
9. School of Pharmacy, University of Missouri-Kansas City. Judith Hemberger Graduate Scholarship. Date: 2014.
10. University of Missouri-Kansas City School of Graduate Studies Research Grant Award . Date: 2014.
Education
- 1. Degree: Ph D. University of Missouri- Kansas City. Date: 2017.
2. Degree: M. Pharm.. Shri G.S. Institute of Technology & Science, India . Date: 2008.
3. Degree: B. Pharm. Shri G.S. Institute of Technology & Science, India . Date: 2005.
Administrative Assignments
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