Vibhuti Agrahari, Ph.D.
Assistant Professor
Pharmaceutical Sciences
Phone 405-271-6751 x47244
Fax 405-271-7505
Office CPB 325
Summary
My research focuses on long-term drug delivery by designing innovative systems such as nanocarriers, micelles, and hydrogels using biomaterials. The research activities include rationale design, optimization, and evaluation of the nanoformulations for local, targeted and sustained delivery of biotherapeutic and small molecule drugs using stimuli-responsive polymers, natural polymers, block- and random- copolymers, etc. The ultimate goal of my research laboratory is to develop biomaterials that can provide selective, controlled, non-toxic, biodegradable, and stimuli-responsive platforms to target therapeutic agents to the sites of ocular and inner ear diseases. My laboratory is specialized in the area of (a) sustained delivery of protein/antibodies for the back of eye diseases. (b) non-invasive treatment, and prevention of vision loss due to ocular injuries. (c) next-generation therapeutics for anterior segment ocular diseases (d) nanotherapeutic approaches to provide a prophylactic cure for Chemotherapeutic-Induced Ototoxicity (CIO).
Grants
New Investigator Grant: "Bio-responsive NanoSensoGel for Prevention of Cisplatin-induced Ototoxity and Hearing Loss"
Presbyterian Health Foundation
07/01/2021 - 06/30/2022CFAR Grant: "ROS-responsive NanoSensoGel for Prevention of Cistplatin-Induced Ototoxicity and Hearing Loss"
Capita Foundation
11/01/2021 - 12/31/2022Publications & Presentations
- 26. Agrahari V, Agrahari V, Hung W, Christenson L K, Mitra A K. Composite Nanoformulation Therapeutics for Long-Term Ocular Delivery of Macromolecules. MOLECULAR PHARMACEUTICS. 2016; 13 : 2912-2922
27. Agrahari V, Agrahari V, Mitra A K. Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities. THERAPEUTIC DELIVERY. 2016; 7 : 257-278
28. Yang X, Shah S J, Wang Z, Agrahari V, Pal D, Mitra A K. Nanoparticle-based topical ophthalmic formulation for sustained release of stereoisomeric dipeptide prodrugs of ganciclovir. DRUG DELIVERY. 2016; 23 : 2399-2409
29. Yang X, Trinh H M, Agrahari V, Sheng Y, Pal D, Mitra A K. Nanoparticle-Based Topical Ophthalmic Gel Formulation for Sustained Release of Hydrocortisone Butyrate. AAPS PHARMSCITECH. 2016; 17 : 294-306
30. Patel S P, Vaishya R, Patel A, Agrahari V, Pal D, Mitra A k. Optimization of novel pentablock copolymer based composite formulation for sustained delivery of peptide/protein in the treatment of ocular diseases. JOURNAL OF MICROENCAPSULATION. 2016; 33 : 103-113
Grants
- 1. Bio-responsive Nano-SensoGel for Prevention of Chemotherapy-Induced Ototoxicity and Hearing Loss . Non-federal. Start Date: 2021. End Date: 2022.
Awards and Honors
- 6. National Biotechnology Conference, AAPS. Biotechnology Graduate Student Symposium Award,. Date: 2016.
7. American Association of Pharmaceutical Scientists. Quality by Design and Product Performance Graduate Student Award. Date: 2016.
8. American Association of Pharmaceutical Scientists. Ocular Drug Delivery Disposition Focus Group (ODDDFG) Award. Date: 2015.
9. School of Pharmacy, University of Missouri-Kansas City. Judith Hemberger Graduate Scholarship. Date: 2014.
10. University of Missouri-Kansas City School of Graduate Studies Research Grant Award . Date: 2014.
Education
- 1. Degree: Ph D. University of Missouri- Kansas City. Date: 2017.
2. Degree: M. Pharm.. Shri G.S. Institute of Technology & Science, India . Date: 2008.
3. Degree: B. Pharm. Shri G.S. Institute of Technology & Science, India . Date: 2005.
Administrative Assignments
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