Vibhuti Agrahari, Ph.D.
Assistant Professor
Pharmaceutical Sciences
Phone 405-271-6751 x47244
Fax 405-271-7505
Office CPB 325
Summary
My research focuses on long-term drug delivery by designing innovative systems such as nanocarriers, micelles, and hydrogels using biomaterials. The research activities include rationale design, optimization, and evaluation of the nanoformulations for local, targeted and sustained delivery of biotherapeutic and small molecule drugs using stimuli-responsive polymers, natural polymers, block- and random- copolymers, etc. The ultimate goal of my research laboratory is to develop biomaterials that can provide selective, controlled, non-toxic, biodegradable, and stimuli-responsive platforms to target therapeutic agents to the sites of ocular and inner ear diseases. My laboratory is specialized in the area of (a) sustained delivery of protein/antibodies for the back of eye diseases. (b) non-invasive treatment, and prevention of vision loss due to ocular injuries. (c) next-generation therapeutics for anterior segment ocular diseases (d) nanotherapeutic approaches to provide a prophylactic cure for Chemotherapeutic-Induced Ototoxicity (CIO).
Grants
New Investigator Grant: "Bio-responsive NanoSensoGel for Prevention of Cisplatin-induced Ototoxity and Hearing Loss"
Presbyterian Health Foundation
07/01/2021 - 06/30/2022CFAR Grant: "ROS-responsive NanoSensoGel for Prevention of Cistplatin-Induced Ototoxicity and Hearing Loss"
Capita Foundation
11/01/2021 - 12/31/2022Publications & Presentations
- 16. Li G, Agrahari V, Agrahari V, Mandal A, Mitra A K, Stamer W D. Delivery of Dexamethasone from Novel Pentablock Copolymer-Based Nanoformulation Promotes Prolonged Secretion of myocilin from Human Trabecular Meshwork Cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017; 58
17. Agrahari V, Agrahari V, Mandal A, Pal D, Mitra A K. How are we improving the delivery to back of the eye? Advances and challenges of novel therapeutic approaches. EXPERT OPINION ON DRUG DELIVERY. 2017; 14 : 1145-1161
18. Agrahari V, Agrahari V, Mitra A K. Inner ear targeted drug delivery: what does the future hold?. THERAPEUTIC DELIVERY. 2017; 8 : 179-184
19. Agrahari V, Agrahari V, Mitra A K. Next generation drug delivery: circulatory cells-mediated nanotherapeutic approaches. EXPERT OPINION ON DRUG DELIVERY. 2017; 14 : 285-289
20. Agrahari V, Li G, Agrahari V, Navarro I, Perkumas K, Mandal A, Stamer W D, Mitra A K. Pentablock copolymer dexamethasone nanoformulations elevate MYOC: in vitro liberation, activity and safety in human trabecular meshwork cells. NANOMEDICINE. 2017; 12 : 1911-1926
Grants
- 1. Bio-responsive Nano-SensoGel for Prevention of Chemotherapy-Induced Ototoxicity and Hearing Loss . Non-federal. Start Date: 2021. End Date: 2022.
Awards and Honors
- 6. National Biotechnology Conference, AAPS. Biotechnology Graduate Student Symposium Award,. Date: 2016.
7. American Association of Pharmaceutical Scientists. Quality by Design and Product Performance Graduate Student Award. Date: 2016.
8. American Association of Pharmaceutical Scientists. Ocular Drug Delivery Disposition Focus Group (ODDDFG) Award. Date: 2015.
9. School of Pharmacy, University of Missouri-Kansas City. Judith Hemberger Graduate Scholarship. Date: 2014.
10. University of Missouri-Kansas City School of Graduate Studies Research Grant Award . Date: 2014.
Education
- 1. Degree: Ph D. University of Missouri- Kansas City. Date: 2017.
2. Degree: M. Pharm.. Shri G.S. Institute of Technology & Science, India . Date: 2008.
3. Degree: B. Pharm. Shri G.S. Institute of Technology & Science, India . Date: 2005.
Administrative Assignments
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