Vibhudutta Awasthi, Ph.D.

Professor and Associate Dean for Research

Pharmaceutical Sciences

Phone (405) 271-6593 x47331

Fax (405) -271-7505

Office CPB 309

Email vibhudutta-awasthi@ouhsc.edu


Summary


My research interests are in the development of radiopharmaceuticals, small animal imaging and use of radiological imaging techniques to answer physiological questions. My current research focuses on the development of liposome encapsulated hemoglobin as an artificial oxygen carrier and he is studying cerebral oxygen metabolism using positron emission tomography. I am a board certified nuclear pharmacist with expertise in areas related to drug delivery, formulation development, nuclear pharmacy and small animal nuclear imaging.



Publications & Presentations

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    41. Rao G, Yadav V, Awasthi S, Roberts P, Awasthi V. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver. 2016; 311 : G180-189

    42. Nkepang G N, Hedrick A F, Awasthi V, Gali H. Facile synthesis of para-[18F]fluorohippurate via iodonium ylide-mediated radiofluorination for PET renography. Bioorg Med Chem Lett. 2016; 26 : 479-83

    43. Pathuri G, Hedrick A F, Awasthi V, Cowley, Jr B D, Gali H. Evaluation of [18F]PFH PET renography to predict future disease progression in a rat model of autosomal dominant polycystic kidney disease. Nucl Med Biol. 2016; 43 : 1-5

    44. Pathuri G, Hedrick A F, January S E, Galbraith W, Awasthi V, Arnold C D, Cowley B D, Gali H. Synthesis and in vivo evaluation of gallium-68-labeled glycine and hippurate conjugates for positron emission tomography renography. J Labelled Compd Rad. 2015; 58 : 14–19

    45. Vilekar P, Rao G, Awasthi S, Awasthi V. Diphenyldifluoroketone EF24 suppresses pro-inflammatory interleukin-1 receptor 1 and toll-like receptor 4 in lipopolysaccharide-stimulated dendritic cells. J Inflamm. 2015; 12 : 55

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Grants

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    6. STTR Phase I: Cardiotropic Atorvastatin Liposomes for Myocardial Reperfusion Injury. NSF. Start Date: 2023. End Date: 2021.

    7. Pharmacotherapy of Traumatic Brain Injury Accompanied by Hemorrhagic Shock. NIH. Start Date: 2017. End Date: 2022.

    8. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

    9. Immunokinetics of superhydrophilic polymer-modified liposome encapsulated hemoglobin. Non-federal. Start Date: 2017. End Date: 2020.

    10. PET Imaging Agent For Myocardial Infarction. NIH. Start Date: 2019. End Date: 2019.

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Awards and Honors

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                                                                                            6. Sandra K and David L Gilliland Chair in Nuclear Pharmacy . Date: 2012.  

                                                                                            7. Indo-American Society of Nuclear Medicine. President. Date: 2010.  

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Education

                                                                                            1.  Degree: Ph D. Sanjay Gandhi Postgraduate Institute of Medical Sciences . Date: 1994.  

                                                                                            2.  Degree: M. Pharm.. Dr. Hari Singh Gour Vishwavidyalaya, Sagar (Formerly, University of Sagar). Date: 1990.  

                                                                                            3.  Degree: B. Pharm. Dr. Hari Singh Gour Vishwavidyalaya, Sagar (Formerly, University of Sagar). Date: 1988.  




Administrative Assignments

                                                

    1. Role: Associate Dean. Scope: College. Description: Lead research enterprise of the College of Pharmacy. Represent the College at the HSC level. Mentor researchers. Date: 2020.

                                                

    2. Role: Director. Scope: University. Description: Direction and conduct of nuclear imaging services for biomedical investigators; Production of PET radiotracers for preclinical imaging and preparation for regulatory compliance for clinical applications; Consultations with researchers about imaging and tracer applications. Date: 2007.




External Connections and Partnerships


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