Randle Gallucci, Ph.D.

Professor/Director of Graduate Programs

Pharmaceutical Sciences

Phone (405) 271-6593 x47188

Fax (405) 271-7505

Office CPB 333

Email randy-gallucci@ouhsc.edu


Summary

The research in my laboratory primarily focuses on the positive and negative roles that inflammatory cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two-fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of techniques including, Luminex Multiplex assay, flow cytometry, and RNAseq. Therapeutic studies have involved the reconstitution of wound healing in models of chronic wounds such diabetic and specific gene knockout mice.




Publications & Presentations

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    16. Lee E G, Mickle-Kawar B M, Gallucci R. IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. Journal of immunotoxicology. 2013; 10 : 192-200

    17. Lee E G, Mickle-Kawar B M, Reinke L A, Gallucci R. Estrogen suppresses heptatic IκB expression during short-term alcohol exposure. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 2012; 61 : 1053-61

    18. Luckett-Chastain L R, Ihnat M, Mickle-Kawar B M, Gallucci R. SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2012; 32 : 207-15

    19. Van Amburgh J, Surratt C K, Green J S, Gallucci R, Colbert J, Zatopek S L, Blouin R A. Succession planning in US pharmacy schools. American journal of pharmaceutical education. 2010; 74

    20. Luckett-Chastain L R, Gallucci R. Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. The British journal of dermatology. 2009; 161 : 237-48

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Grants

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    6. The role of specific inflammatory mediators in keratinocyte function and wound healing. Misc Non-Federal. Start Date: 2018. End Date: 2019.

    7. The role of IL-6 receptor in irritant dermatitis. CDC. Start Date: 2013. End Date: 2017.

    8. Modulation of Inflammatory Mechanisms Underlying Chronic Pain of Posttraumatic Stress Disorder: Prevention and Treatment. Misc Non-Federal. Start Date: 2015. End Date: 2016.

    9. Molecular mechanisms of chronic pain and its modulation by posttraumatic stress disorder and Nociceptin/Orphanin FQ. DOD. Start Date: 2011. End Date: 2015.

    10. Dermatological Effects of Gulf Oil. NIH. Start Date: 2012. End Date: 2014.

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Awards and Honors

                                                                                            1. OUHSC. OUHSC President's Associates Professorship. Date: 2017.  

                                                                                            2. OUHSC. Provost's Junior Faculty Research Award. Date: 2005.  




Education

                                                                                            1.  Degree: Ph D. Washington State University. Date: 1995.  

                                                                                            2.  Degree: BA. Central Washington University. Date: 1987.  




Administrative Assignments

                                                

    1. Role: Director. Scope: College. Description: Oversee the graduate programs within the College of Pharmacy. Date: 2023.