1. Role: Director. Scope: College. Description: Oversee the graduate programs within the College of Pharmacy. Date: 2023.
Randle Gallucci, Ph.D.
Professor/Director of Graduate Programs
Pharmaceutical Sciences
Phone (405) 271-6593 x47188
Fax (405) 271-7505
Office CPB 333
Email randy-gallucci@ouhsc.edu
Summary
The research in my laboratory primarily focuses on the positive and negative roles that inflammatory cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two-fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of techniques including, Luminex Multiplex assay, flow cytometry, and RNAseq. Therapeutic studies have involved the reconstitution of wound healing in models of chronic wounds such diabetic and specific gene knockout mice.
Publications & Presentations
- 11. Calhoun K N, Luckett-Chastain L R, Frempah B, Gallucci R. Associations Between Immune Phenotype and Inflammation in Murine Models of Irritant Contact Dermatitis. Toxicological Sciences/Oxford. 2019; 168 : 179-189
12. Luckett-Chastain L R, Gipson J R, Gillaspy A F, Gallucci R. Transcriptional profiling of irritant contact dermatitis (ICD) in a mouse model identifies specific patterns of gene expression and immune-regulation. Toxicology/Elsevier. 2018; 410 : 1-9
13. Yucesoy B, Gallucci R. Systems Biology in Immunotoxicology. Elsevier Ltd. 2018 : 559-581
14. Gallucci R. Transforming growth factor-β and psoriasis: a new link. British journal of Dermatology. 2017; 177 : 1480-1481
15. Luckett-Chastain L R, Smith M L, Mickle B M, Ihnat M, Gallucci R. Interleukin (IL)-6 modulates transforming growth factor -β receptor II (TGF-βRII) function in epidermal keratinocytes. Experimental Dermatology. 2017; 26 : 697-704
Grants
- 6. The role of specific inflammatory mediators in keratinocyte function and wound healing. Misc Non-Federal. Start Date: 2018. End Date: 2019.
7. The role of IL-6 receptor in irritant dermatitis. CDC. Start Date: 2013. End Date: 2017.
8. Modulation of Inflammatory Mechanisms Underlying Chronic Pain of Posttraumatic Stress Disorder: Prevention and Treatment. Misc Non-Federal. Start Date: 2015. End Date: 2016.
9. Molecular mechanisms of chronic pain and its modulation by posttraumatic stress disorder and Nociceptin/Orphanin FQ. DOD. Start Date: 2011. End Date: 2015.
10. Dermatological Effects of Gulf Oil. NIH. Start Date: 2012. End Date: 2014.
Awards and Honors
- 1. OUHSC. OUHSC President's Associates Professorship. Date: 2017.
2. OUHSC. Provost's Junior Faculty Research Award. Date: 2005.
Education
- 1. Degree: Ph D. Washington State University. Date: 1995.
2. Degree: BA. Central Washington University. Date: 1987.