H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

<< 6 7 8 9 10 > >>
    41. Pohl J, Pereira H A, Martin N M, Spitznagel J K. Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase. FEBS letters. 1990; 272 : 200-4

    42. Pereira H A, Spitznagel J K, Winton E F, Shafer W M, Martin L E, Guzman G S, Pohl J, Scott R W, Marra M N, Kinkade, Jr J M. The ontogeny of a 57-Kd cationic antimicrobial protein of human polymorphonuclear leukocytes: localization to a novel granule population. Blood. 1990; 76 : 825-34

    43. Pereira H A, Shafer W M, Pohl J, Martin L E, Spitznagel J K. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. The Journal of clinical investigation. 1990; 85 : 1468-76

    44. Pereira H A, Spitznagel J K, Pohl J, Wilson D E, Morgan J, Palings I, Larrick J W. CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. Life sciences. 1990; 46 : 189-96

    45. Pereira H A, Martin L E, Spitznagel J K. Quantitation of a cationic antimicrobial granule protein of human polymorphonuclear leukocytes by ELISA. Journal of immunological methods. 1989; 117 : 115-20

<< 6 7 8 9 10 > >>



Grants

1 2 3 4 >>
    1. Vision Science Training Program. NIH. Start Date: 2021. End Date: 2026.

    2. STTR Phase 1: Multi-target Peptide Drug for Alzheimer's Disease. NIA. Start Date: 2024. End Date: 2025.

    3. STTR Phase 1: Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2023.

    4. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2018. End Date: 2023.

    5. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

1 2 3 4 >>



Awards and Honors

1 2 3 4 >>
                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            4. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

1 2 3 4 >>



Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.