H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    31. Brackett D J, Lerner M R, Lacquement M A, He R, Pereira H A. A synthetic lipopolysaccharide-binding peptide based on the neutrophil-derived protein CAP37 prevents endotoxin-induced responses in conscious rats. Infection and immunity. 1997; 65 : 2803-11

    32. Pereira H A. Assay systems for measurement of chemotactic activity. Methods in molecular biology (Clifton, N.J.). 1997; 78 : 233-46

    33. Brackett D J, Lerner M R, Pereira H A. Neutralization of the in vivo activity of E. coli-derived lipopolysaccharide by cationic peptides. Methods in molecular biology (Clifton, N.J.). 1997; 78 : 247-55

    34. Pereira H A, Moore P, Grammas P. CAP37, a neutrophil granule-derived protein stimulates protein kinase C activity in endothelial cells. Journal of leukocyte biology. 1996; 60 : 415-22

    35. Aragon A S, Pereira H A, Baca O G. A cationic antimicrobial peptide enhances the infectivity of Coxiella burnetii. Acta virologica. 1995; 39 : 223-226

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Grants

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    1. Vision Science Training Program. NIH. Start Date: 2021. End Date: 2026.

    2. STTR Phase 1: Multi-target Peptide Drug for Alzheimer's Disease. NIA. Start Date: 2024. End Date: 2025.

    3. STTR Phase 1: Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2023.

    4. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2018. End Date: 2023.

    5. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

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Awards and Honors

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                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            4. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.