H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    36. D'Cruz O J, Pereira H A, Haas, Jr G G. Sperm immobilizing activity of a synthetic bioactive peptide 20-44 of 37-kDa cationic antimicrobial protein (CAP37) of human neutrophils. Journal of andrology. 1995; 16 : 432-40

    37. Pereira H A. CAP37, a neutrophil-derived multifunctional inflammatory mediator. Journal of leukocyte biology. 1995; 57 : 805-12

    38. Pereira H A, Erdem I, Pohl J, Spitznagel J K. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90 : 4733-7

    39. Morgan J G, Sukiennicki T, Pereira H A, Spitznagel J K, Guerra M E, Larrick J W. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. Journal of immunology (Baltimore, Md. : 1950). 1991; 147 : 3210-4

    40. Morgan J G, Pereira H A, Sukiennicki T, Spitznagel J K, Larrick J W. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. Advances in experimental medicine and biology. 1991; 305 : 89-96

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Grants

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    16. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.

    17. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.

    18. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.

    19. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.

    20. Role of CAP37 in Neuroinflammation: Friend or Foe?. State Agency. Start Date: 2012. End Date: 2015.

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Awards and Honors

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                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            4. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.