Wei Yue, Ph.D.
Associate Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x47828
Fax (405) 271-7505
Office CPB 328
Email wei-yue@ouhsc.edu
Faculty Website https://sites.google.com/view/yuelab
Summary
My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.
Academic Awards
Member, Educators for Excellence
OUHSC
April 2022Publications & Presentations
- 26. Yang K, Pfeifer N D, Hardwick R N, Yue W, Stewart P W, Brouwer K L. An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR- Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown. Molecular pharmaceutics. 2014
27. Bheda A, Yue W, Gullapalli A, Shackelford J, Pagano J S. PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells. Leukemia & lymphoma. 2011; 52 : 1336-47
28. Marion T L, Perry C H, St Claire, 3rd R L, Yue W, Brouwer K L. Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2011; 120 : 371-80
29. Yue W, Lee J K, Abe K, Sugiyama Y, Brouwer K L. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats. Drug metabolism and disposition: the biological fate of chemicals. 2011; 39 : 441-7
30. Swift B, Yue W, Brouwer K L. Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes. Pharmaceutical research. 2010; 27 : 1987-98
Grants
- 1. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.
2. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . Misc Non-Federal. Start Date: 2022. End Date: 2022.
3. Lysine Acetylation: A novel mechanism governing organic anion transporting polypeptides OATP1B1- and OATP1B3-mediated transport. Misc Non-Federal. Start Date: 2021. End Date: 2022.
4. Elucidating novel mechanism underlying OATP1B1/1B3-mediated drug-drug interactions . Non-federal. Start Date: 2019. End Date: 2020.
5. Characterize ADME of compound X. Non-federal. Start Date: 2019. End Date: 2020.
Awards and Honors
- 1. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.
2. Shandong University, China. Sunshine scholarship. Date: 1996.
Education
- 1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.
2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.
3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.
4. Degree: MS. Shandong University, China. Date: 1998.
5. Degree: BS. Shandong Agricultural University, China. Date: 1995.
Administrative Assignments
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