Shanjana Awasthi, Ph.D.

---

Summary

Research in my lab is focused on developing immunotherapeutics and vaccines by harnessing our body's natural host defense mechanisms. Our research efforts have been focused on developing TLR4-interacting surfactant protein-A-derived peptides and dendritic cell-based vaccine approaches. We are interested in investigating the mechanisms of action and efficacy of these approaches using structural, computational, physicochemical, and immunological tools and methods, and in vitro and in animal models of infection, inflammation and cancer.

Certifications & Licenses

---

Publications & Presentations

31. Garcia-Contreras L, Awasthi S, Hanif S N, Hickey A J. Inhaled vaccines for the prevention of tuberculosis. Mycobact Dis. 2012; S : http://dx.doi.org/10.4172/2161-1068.S1-002

32. Moriasi C, Subramaniam D, Awasthi S, Ramalingam S, Anant S. Prevention of Colitis-associated Cancer: Natural Compounds that Target the IL-6 Soluble Receptor. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2012; 12 : 1221-1238

33. Madhusoodhanan R, Moriasi C, Ramani V, Anant S, Awasthi S. A TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells. Oncoimmunology. 2012; 1 : 1495-1506

34. Langer M, Duggan E S, Booth J L, Patel V I, Zander R A, Silasi-Mansat R, Ramani V, Veres T Z, Prenzler F, Sewald K, Williams D M, Coggeshall K M, Awasthi S, Lupu F, Burian D, Ballard J D, Braun A, Metcalf J P. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infection and immunity. 2012; 80 : 4374-87

35. Daw K, Baghdayan A S, Awasthi S, Shankar N. Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro. FEMS immunology and medical microbiology. 2012; 65 : 270-82

Grants

1. Surfactant protein-A regions as TLR4-immunomodulators. NIH. Start Date: 2017. End Date: 2023.

2. Molecular mechanism of action of TLR4-interacting SPA4 peptide in lung epithelial cell systems. Non-federal. Start Date: 2021. End Date: 2022.

3. Immunomodulation by a TLR4-interacting Surfactant protein-A peptide. Non-federal. Start Date: 2013. End Date: 2021.

4. Control of lung inflammation by a TLR4-interacting SP-A-derived peptide. NIH. Start Date: 2013. End Date: 2017.

5. Structure-function relation of a TLR4-interacting Surfactant protein-A-derived peptide. NIH. Start Date: 2013. End Date: 2014.

Awards and Honors

1. Office of Technology Development, OUHSC. Patent Award. Date: 2014.


2. Tech Connect Ventures in partnership with Blue Origin and Sierra Space. Finalist of Reef Starter Innovation Challenge. Date: 2022.

Education

1. Degree: Post-Baccalaureate Categorical certificate in Clinical Microbiology. University of Texas Health Sciences Center at San Antonio. Date: 2006.


2. Degree: Ph D. Sanjay Gandhi Post Graduate Institute of Medical Sciences. Date: 1995.


3. Degree: Master of Science. Indian Institute of Technology (IIT). Date: 1990.


4. Degree: Bachelor of Science. MKP College, University of Garhwal. Date: 1988.

Administrative Assignments

no results

External Connections and Partnerships

1. Type: Funding. Org: Oklahoma State University (2013-2017). City: Stillwater. State: Oklahoma. NIH-supported COBRE program in Respiratory and Infectious Diseases. Date: 2013.


2. Type: Funding. Org: University of Oklahoma (2013-2014). City: Norman. State: Oklahoma. NIH-supported COBRE program in Structural Biology. Date: 2013.