Randle Gallucci, Ph.D.

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Summary

The research in my laboratory primarily focuses on the positive and negative roles that inflammatory cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two-fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of techniques including, Luminex Multiplex assay, flow cytometry, and RNAseq. Therapeutic studies have involved the reconstitution of wound healing in models of chronic wounds such diabetic and specific gene knockout mice.

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Publications & Presentations

11. Calhoun K N, Luckett-Chastain L R, Frempah B, Gallucci R. Associations Between Immune Phenotype and Inflammation in Murine Models of Irritant Contact Dermatitis. Toxicological Sciences/Oxford. 2019; 168 : 179-189

12. Luckett-Chastain L R, Gipson J R, Gillaspy A F, Gallucci R. Transcriptional profiling of irritant contact dermatitis (ICD) in a mouse model identifies specific patterns of gene expression and immune-regulation. Toxicology/Elsevier. 2018; 410 : 1-9

13. Yucesoy B, Gallucci R. Systems Biology in Immunotoxicology. Elsevier Ltd. 2018 : 559-581

14. Gallucci R. Transforming growth factor-β and psoriasis: a new link. British journal of Dermatology. 2017; 177 : 1480-1481

15. Luckett-Chastain L R, Smith M L, Mickle B M, Ihnat M, Gallucci R. Interleukin (IL)-6 modulates transforming growth factor -β receptor II (TGF-βRII) function in epidermal keratinocytes. Experimental Dermatology. 2017; 26 : 697-704

Grants

1. The Macrophage/Tuft Cell Axis in SUCNR1 Sensing of Extracellular Succinate in Neonatal Intestinal Inflammation. NIAID. Start Date: 2023. End Date: 2025.

2. Experimental and computational studies to identify optimal conditions for immune-cytotoxic combination therapy. State Agency. Start Date: 2022. End Date: 2024.

3. Nephrotoxic mechanisms of low-rank coal (lignite) leachates in drinking wate. NIH. Start Date: 2020. End Date: 2023.

4. Effect of end-toxemia on colchicine plasma levels. ACCP. Start Date: 2022. End Date: 2022.

5. The effects of CCR3 antagonism on diabetic healing in an outbred strain of mouse.. Misc Non-Federal. Start Date: 2020. End Date: 2021.

Awards and Honors

1. OUHSC. OUHSC President's Associates Professorship. Date: 2017.


2. OUHSC. Provost's Junior Faculty Research Award. Date: 2005.

Education

1. Degree: Ph D. Washington State University. Date: 1995.


2. Degree: BA. Central Washington University. Date: 1987.

Administrative Assignments

1. Role: Director. Scope: College. Description: Oversee the graduate programs within the College of Pharmacy. Date: 2023.
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