Randle Gallucci, Ph.D.

Professor

Department of Pharmaceutical Sciences

Phone (405) 271-6593 x47188

Fax (405) 271-7505

Office CPB 333

Email randy-gallucci@ouhsc.edu


Summary

The research in my laboratory primarily focuses on the positive and negative roles that inflammatory cytokines play during the repair or restoration of injured tissues. I am currently investigating these effects in both skin and liver utilizing both in vivo and in vitro models. The purpose of these studies is two-fold: 1) to elucidate the mechanism of, and identify factors involved in, the transcriptional or post-transcriptional regulation of genes modulated by various pro-inflammatory cytokines, and 2) to determine if any of these pro-inflammatory mediators may be useful therapeutically. To investigate the former, we have employed a variety of techniques including, Luminex Multiplex assay, flow cytometry, and RNAseq. Therapeutic studies have involved the reconstitution of wound healing in models of chronic wounds such diabetic and specific gene knockout mice.




Education & Experience

Ph.D. in Pharmacology/Toxicology

Washington State University

B.A. in Chemistry/Biology

Central Washington University



Honors & Awards

Professional Awards

OUHSC Provost's Junio Faculty Research Award




Publications & Presentations

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  1. Lee E G, Luckett-Chastain l R, Calhoun K, Frempah B, Bastian A, Gallucci R. Interleukin 6 function in skin and isolated keratinocytes is modulated by hyperglycemia. Journal of Immunology Research. In Press
  2. Calhoun K N, Luckett-Chastain L R, Frempah B, Gallucci R. Associations Between Immune Phenotype and Inflammation in Murine Models of Irritant Contact Dermatitis. Toxicological Sciences/Oxford. 2018
  3. Luckett-Chastain L R, Gipson J R, Gillaspy A F, Gallucci R. Transcriptional profiling of irritant contact dermatitis (ICD) in a mouse model identifies specific patterns of gene expression and immune-regulation. Toxicology/Elsevier. 2018; 410 : 1-9
  4. Kemp J M, Luckett L R, Calhoun K N, Frempah B, Schartz T R, Harty L E, Kemp P M, Gallucci R. EVALUATION OF SKIN INFLAMMATION ASSOCIATED WITH WEATHERED AND FRESH CRUDE OIL EXPOSURE IN TWO MOUSE STRAINS. Journal of Toxicology and Environmental Health/Taylor and Francis. In Press
  5. Ojeda A S, Ford S D, Gallucci R, Ihnat M, Philp R P. Geochemical characterization and renal cell toxicity of water-soluble extracts from U.S. Gulf Coast lignite. Environ Geochem Health/Springer. 2018
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Grants

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  • The role of inflammatory mediators and microbiome in aging skin wounds. 2018.
  • Context-dependence of dormancy and drug resistance. 2019.
  • Nephrotoxic mechanisms of low-rank coal (lignite) leachates in drinking wate. 2019.
  • Time-dependent treatment: Early blockade of TNF prevents development of PTSD and co-morbid allodynia. 2018.
  • . 2016.
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