Lucila Garcia-Contreras, Ph.D.

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Summary

The research goal of my laboratory is “Targeted Drug Delivery” and involves the rational design of dosage forms and their in vitro evaluation, which are used to design in vivo studies. In turn, the information obtained in in vitro and in vivo studies is used to understand the underlying reasons of the performance of the dosage form with the objective of improving its formulation design to achieve the desired therapeutic effect. 

   A recent project that illustrates this process is the formulation of a novel molecule with anticancer and antimicrobial activity for pulmonary delivery as nanocrystals or microparticles. In vitro evaluation included size analysis using Scanning Electron Microscopy (SEM) and laser diffraction; stability, using (Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). We determined the aerosol performance of these formulations using commercial dry powder inhalers and performed pharmacokinetic studies to determine the disposition of the drug after pulmonary administration to mice. Lastly, in collaboration with Dr. Jie Wu from the OUHSC Department of Pathology, we assessed the efficacy of the nanocrystals in a transgenic mouse model of adenocarcinoma.

   My laboratory also designs dosage forms for oral, vaginal and transdermal administration following same procedure.  A second line of investigation of my laboratory is the development of needle-less vaccines to provide mucosal and systemic immunization. We are interested in elucidating the role of cell mediated immune (CMI) response and humoral immunity to the overall protection provided by the vaccine. Examples of vaccines studied in my laboratory include vaccines against tuberculosis, West Nile Virus, Diphtheria and Shigellosis.

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Publications & Presentations

1. Yue W, Farasyn T, Crowe A, Alam K, Garcia-Contreras L, Tu Y, Wang L. Transporters in hepatic and intestinal uptake of orally administered drugs. John Wiley & Sons, Inc. 2024

2. Garcia-Contreras L, Hanif S S, Ibrahim M, Durham P, HIckey A J. The Pharmacokinetics of CPZEN-45, a Novel Anti-Tuberculosis Drug, in Guinea Pigs. Pharmaceutics . 2023; 15 : 2758

3. Beathard A, Garcia-Contreras L. OHet72 Nanocrystals for the Treatment of Head and Neck Cancer: Effect of Polymorphic Forms on the Physicochemical Properties of Nanocrystals. End to Cancer Research Symposium. SCC OUHSC. 2023

4. Wang L, Quine S, Lee M, Yang W, Frickenstein A N, Sheth V M, Bourlon M D, Garcia-Contreras L, Zhao Y D, Wilhelm S. Exploring and Analyzing the Systemic Delivery Barriers for Nanoparticles. Advanced Functional Materials. 2023; DOI: 10.1002/adfm.202308446

5. Beathard A, Garcia-Contreras L. Polymorphism of OHet72 Nanocrystals - Impact of Solvent on Nanocrystal Formation. 2023 Southwest Regional Meeting, American Chemical Society. 2023

Grants

11. Inhalable Microparticulate SHetA2 Nanocrystals for Lung Cancer Treatment. State Agency. Start Date: 2016. End Date: 2017.

12. Stable Needleless Vaccine against Shigella spp. NIH. Start Date: 2014. End Date: 2017.

13. Development of SHetA2 vaginal suppositories for treatment of cervical dysplasia. Misc Non-Federal. Start Date: 2015. End Date: 2015.

14. Inhaled SHetA2 (NSC 721689) dry powder aerosols as novel treatment for tuberculosis. Non-federal. Start Date: 2014. End Date: 2015.

15. Development of SHetA2 vaginal suppositories for treatment of cervical dysplasia. Misc Non-Federal. Start Date: 2015. End Date: 2015.

Awards and Honors

6. National Autonomous University of Mexico. Gabino Barreda Medal-UNAM. Date: 1991.

Education

1. Degree: Post doctoral education. the University of North Carolina at Chapel Hill. Date: 2001.


2. Degree: Ph D. The University of Georgia. Date: 1999.


3. Degree: MS. The University of Georgia. Date: 1995.


4. Degree: Chemist Pharmacist Biologist. National Autonomous University of Mexico. Date: 1991.

Administrative Assignments

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