Lucila Garcia-Contreras, Ph.D.

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Summary

The research goal of my laboratory is “Targeted Drug Delivery” and involves the rational design of dosage forms and their in vitro evaluation, which are used to design in vivo studies. In turn, the information obtained in in vitro and in vivo studies is used to understand the underlying reasons of the performance of the dosage form with the objective of improving its formulation design to achieve the desired therapeutic effect. 

   A recent project that illustrates this process is the formulation of a novel molecule with anticancer and antimicrobial activity for pulmonary delivery as nanocrystals or microparticles. In vitro evaluation included size analysis using Scanning Electron Microscopy (SEM) and laser diffraction; stability, using (Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). We determined the aerosol performance of these formulations using commercial dry powder inhalers and performed pharmacokinetic studies to determine the disposition of the drug after pulmonary administration to mice. Lastly, in collaboration with Dr. Jie Wu from the OUHSC Department of Pathology, we assessed the efficacy of the nanocrystals in a transgenic mouse model of adenocarcinoma.

   My laboratory also designs dosage forms for oral, vaginal and transdermal administration following same procedure.  A second line of investigation of my laboratory is the development of needle-less vaccines to provide mucosal and systemic immunization. We are interested in elucidating the role of cell mediated immune (CMI) response and humoral immunity to the overall protection provided by the vaccine. Examples of vaccines studied in my laboratory include vaccines against tuberculosis, West Nile Virus, Diphtheria and Shigellosis.

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Publications & Presentations

56. Ibrahim M, Hatipoglu M K, Garcia-Contreras L. SHetA2 Dry Powder Aerosols for Tuberculosis: Formulation, Design, and Optimization Using Quality by Design. Molecular pharmaceutics. 2017; 15 : 300-313

57. Garcia-Contreras L, Padilla-Carlin D J, Sung J, VerBerkmoes J, Muttil P, Elbert K, Peloquin C, Edwards D, Hickey A. Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs. Journal of pharmaceutical sciences. 2017; 106 : 331-337

58. Ibrahim M, Garcia-Contreras L. Preclinical Pharmacokinetics of Antitubercular Drugs. John Wiley & Sons, Ltd.. 2016

59. Hatipoglu S M, Mahjabeen S, Benbrook D M, Garcia-Contreras L. Development and Validation of Reverse Phase HPLC Method for SHetA2 in Gynecological Tissue for Treatment of Cervical Dysplasia. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition. 2016

60. Ibrahim M, Hatipoglu S M, Benbrook D M, Garcia-Contreras L. Dissolution Studies for Inhalable Sheta2 Dry Powder Using a Novel Flow-Through Cell Apparatus. American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition. 2016

Grants

6. Micronization of EXT4U for toxicological studies . Misc Non-Federal. Start Date: 2023. End Date: 2024.

7. STTR Phase 1: Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2023.

8. Drug Targeting Oxysterol-Binding Protein (OSBP) for Antiviral Treatment of SARS-CoV-2 Infections. Intramural Funding. Start Date: 2022. End Date: 2023.

9. Understanding the effects of sphero-cylinder drug particle shape to enhance small-airway drug delivery for better emphysema treatment outcomes. Misc Non-Federal. Start Date: 2019. End Date: 2022.

10. Targeting HPV Consequences in a Cervical Cancer Clinical Trial. NIH. Start Date: 2016. End Date: 2022.

Awards and Honors

6. National Autonomous University of Mexico. Gabino Barreda Medal-UNAM. Date: 1991.

Education

1. Degree: Post doctoral education. the University of North Carolina at Chapel Hill. Date: 2001.


2. Degree: Ph D. The University of Georgia. Date: 1999.


3. Degree: MS. The University of Georgia. Date: 1995.


4. Degree: Chemist Pharmacist Biologist. National Autonomous University of Mexico. Date: 1991.

Administrative Assignments

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