H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    21. Gordon Y J, Romanowski E G, Shanks R M, Yates K A, Hinsley H, Pereira H A. CAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1. Current eye research. 2009; 34 : 241-9

    22. Pereira H A. Novel therapies based on cationic antimicrobial peptides. Current pharmaceutical biotechnology. 2006; 7 : 229-34

    23. Pereira H A, Ruan X, Gonzalez M L, Tsyshevskaya-Hoover I, Chodosh J. Modulation of corneal epithelial cell functions by the neutrophil-derived inflammatory mediator CAP37. Investigative ophthalmology & visual science. 2004; 45 : 4284-92

    24. Gonzalez M L, Ruan X, Kumar P, Grammas P, Pereira H A. Functional modulation of smooth muscle cells by the inflammatory mediator CAP37. Microvascular research. 2004; 67 : 168-81

    25. Lee T D, Gonzalez M L, Kumar P, Grammas P, Pereira A. CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers. Microvascular research. 2003; 66 : 38-48

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Grants

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    11. Wound Healing Mechanisms Modulated by Novel Antimicrobial Peptides. NIH. Start Date: 2016. End Date: 2019.

    12. 51st Annual Meeting of the Society for Leukocyte Biology (SLB) – Myeloid Cells: Development, Environment and Inflammation. NIH. Start Date: 2018. End Date: 2019.

    13. 50th Annual Meeting of the Society for Leukocyte Biology – Leukocyte Memory: Health and Disease. NIH. Start Date: 2017. End Date: 2018.

    14. Oklahoma Shared Clinical & Translational Resources. NIH. Start Date: 2013. End Date: 2018.

    15. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.

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Awards and Honors

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                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            4. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.