1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
H. Anne Pereira, Ph.D.
Dean, Graduate College and David L. Boren Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x58034
Fax (405) 271-7505
Office CPB 329
Email anne-pereira@ouhsc.edu
Summary
My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Research
This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Patents
Biomarker and method for detecting a chronic inflammatory-associated disease
Patent No. 8,450,071
USA
H. Anne Pereira
Publications & Presentations
- 11. Silasi-Mansat R, Zhu H, Georgescu C, Popescu N, Keshari R S, Peer G, Lupu C, Taylor F B, Pereira H A, Kinasewitz G, Lambros J D, Lupu F. Complement inhibition decreases early fibrogenic events in the lung of septic baboons. Journal of cellular and molecular medicine. 2015; 19 : 2549-63
12. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira H A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. 2015; 144 : 293-308
13. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. Histochemistry and cell biology. 2015; 144 : 293-308
14. Lawrence S M, Eckert J, Makoni M, Pereira H A. Is the Use of Complete Blood Counts with Manual Differentials an Antiquated Method of Determining Neutrophil Composition in Newborns?. Annals of clinical and laboratory science. 2015; 45 : 403-13
15. Kasus-Jacobi A, Noor-Mohammadi S, Griffith G L, Hinsley H, Mathias L, Pereira A. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties. Journal of leukocyte biology. 2015; 97 : 341-50
Grants
- 6. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.
7. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.
8. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.
9. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.
10. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.
Awards and Honors
- 6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.
7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.
8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.
9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.
10. Department of Pathology. Fred G Silva Research Award. Date: 1999.
Education
- 1. Degree: Ph D. University of Melbourne. Date: 1982.
2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.
3. Degree: BS. University of Melbourne. Date: 1975.
Administrative Assignments
2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.