H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

1 2 3 4 > >>
    1. Hughes O, Bentley A R, Breeze C E, Aguet F, Xu X, Nadkarni G, Sun Q, Lin B M, Gilliland T, Meyer M C, Du J, Raffield L M, Kramer H, Morton R W, Gouveia M H, Atkinson E G, Valladares-Salgado A, Wacher-Rodarte N, Dueker N D, Guo X, Hai Y, Adeyemo A, Best L G, Cai J, Chen G, Chong M, Doumatey A, Eales J, Goodarzi M O, Ipp E, Irvin M R, Jiang M, Jones A C, Kooperberg C, Krieger J E, Lange E M, Lanktree M B, Lash J P, Lotufo P A, Ha My V T, Peralta-Romero J, Qi L, Raffel L J, Rich S S, Rodriquez E J, Tarazona-Santos E, Taylor K D, Umans J G, Wen J, Young B A, Yu Z, Zhang Y, Ida Chen Y D, Rundek T, Rotter J I, Cruz M, Fornage M, Lima-Costa M F, Pereira A, Paré G, Natarajan P, Cole S A, Carson A P, Lange L A, Li Y, Perez-Stable E J, Do R, Charchar F J, Tomaszewski M, Mychaleckyj J C, Rotimi C, Morris A P, Franceschini N. Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. Cell genomics. 2023

    2. Kasus-Jacobi A, Washburn J L, Laurence R B, Pereira A. Selecting Multitarget Peptides for Alzheimer's Disease. Biomolecules. 2022; 12 : 1386

    3. Kasus-Jacobi A, Washburn J, Land C, Pereira A. Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity. Current Alzheimer Research. 2021; 18 : 414-427

    4. Kasus-Jacobi A, Land C, Stock A, Washburn J, Pereira A. Antimicrobial peptides derived from the immune defense protein CAP37 inhibit TLR4 activation by S100A9. Investigative Ophthalmology & Visual Science/Association for Research in Vision and Ophthalmology. 2020

    5. Stock A J, Kasus-Jacobi A, Pereira A. The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease. Journal of neuroinflammation. 2018; 15 : 240

1 2 3 4 > >>



Grants

<< 1 2 3 4 5 >>
    11. Wound Healing Mechanisms Modulated by Novel Antimicrobial Peptides. NIH. Start Date: 2016. End Date: 2019.

    12. 51st Annual Meeting of the Society for Leukocyte Biology (SLB) – Myeloid Cells: Development, Environment and Inflammation. NIH. Start Date: 2018. End Date: 2019.

    13. 50th Annual Meeting of the Society for Leukocyte Biology – Leukocyte Memory: Health and Disease. NIH. Start Date: 2017. End Date: 2018.

    14. Oklahoma Shared Clinical & Translational Resources. NIH. Start Date: 2013. End Date: 2018.

    15. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.

<< 1 2 3 4 5 >>



Awards and Honors

1 2 3 4 >>
                                                                                            1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.  

                                                                                            2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.  

                                                                                            3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.  

                                                                                            4. Journal Record. Journal Record Innovator of the Year. Date: 2016.  

                                                                                            5. National Academy of Inventors. Fellow. Date: 2015.  

1 2 3 4 >>



Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.