H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    11. Stock A J, Kasus-Jacobi A, Wren J, Sjoelund V, Prestwich G, Pereira H A. The role of neutrophil proteins on the amyloid beta-RAGE axis. Plos One. 2016

    12. Silasi-Mansat R, Zhu H, Georgescu C, Popescu N, Keshari R S, Peer G, Lupu C, Taylor F B, Pereira H A, Kinasewitz G, Lambros J D, Lupu F. Complement inhibition decreases early fibrogenic events in the lung of septic baboons. Journal of cellular and molecular medicine. 2015; 19 : 2549-63

    13. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira H A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. 2015; 144 : 293-308

    14. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. Histochemistry and cell biology. 2015; 144 : 293-308

    15. Lawrence S M, Eckert J, Makoni M, Pereira H A. Is the Use of Complete Blood Counts with Manual Differentials an Antiquated Method of Determining Neutrophil Composition in Newborns?. Annals of clinical and laboratory science. 2015; 45 : 403-13

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Grants

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    11. Wound Healing Mechanisms Modulated by Novel Antimicrobial Peptides. NIH. Start Date: 2016. End Date: 2019.

    12. 51st Annual Meeting of the Society for Leukocyte Biology (SLB) – Myeloid Cells: Development, Environment and Inflammation. NIH. Start Date: 2018. End Date: 2019.

    13. 50th Annual Meeting of the Society for Leukocyte Biology – Leukocyte Memory: Health and Disease. NIH. Start Date: 2017. End Date: 2018.

    14. Oklahoma Shared Clinical & Translational Resources. NIH. Start Date: 2013. End Date: 2018.

    15. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.

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Awards and Honors

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                                                                                            6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.  

                                                                                            7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.  

                                                                                            8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.  

                                                                                            9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.  

                                                                                            10. Department of Pathology. Fred G Silva Research Award. Date: 1999.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.