1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
H. Anne Pereira, Ph.D.
Dean, Graduate College and David L. Boren Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x58034
Fax (405) 271-7505
Office CPB 329
Email anne-pereira@ouhsc.edu
Summary
My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Research
This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Patents
Biomarker and method for detecting a chronic inflammatory-associated disease
Patent No. 8,450,071
USA
H. Anne Pereira
Publications & Presentations
- 31. Pereira H A. Assay systems for measurement of chemotactic activity. Methods in molecular biology (Clifton, N.J.). 1997; 78 : 233-46
32. Brackett D J, Lerner M R, Pereira H A. Neutralization of the in vivo activity of E. coli-derived lipopolysaccharide by cationic peptides. Methods in molecular biology (Clifton, N.J.). 1997; 78 : 247-55
33. Pereira H A, Moore P, Grammas P. CAP37, a neutrophil granule-derived protein stimulates protein kinase C activity in endothelial cells. Journal of leukocyte biology. 1996; 60 : 415-22
34. Aragon A S, Pereira H A, Baca O G. A cationic antimicrobial peptide enhances the infectivity of Coxiella burnetii. Acta virologica. 1995; 39 : 223-226
35. D'Cruz O J, Pereira H A, Haas, Jr G G. Sperm immobilizing activity of a synthetic bioactive peptide 20-44 of 37-kDa cationic antimicrobial protein (CAP37) of human neutrophils. Journal of andrology. 1995; 16 : 432-40
Grants
- 6. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.
7. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.
8. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.
9. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.
10. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.
Awards and Honors
- 11. The Journal Record. On the Brink, Award for Innovation. Date: 2006.
12. Department of Pathology. Fred G Silva Research Award. Date: 1999.
13. American Heart Association. Established Investigator. Date: 1998.
14. OUHSC. Provosts' Research Award to Junior Faculty. Date: 1994.
15. OUHSC. Faculty Leadership Program. Date: 1992.
Education
- 1. Degree: Ph D. University of Melbourne. Date: 1982.
2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.
3. Degree: BS. University of Melbourne. Date: 1975.
Administrative Assignments
2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.