H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    26. Ruan X, Chodosh J, Callegan M C, Booth M C, Lee T D, Kumar P, Gilmore M S, Pereira H A. Corneal expression of the inflammatory mediator CAP37. Investigative ophthalmology & visual science. 2002; 43 : 1414-21

    27. Lee T D, Gonzalez M L, Kumar P, Chary-Reddy S, Grammas P, Pereira H A. CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions. The American journal of pathology. 2002; 160 : 841-8

    28. Pereira H A. Cationic antimicrobial protein of Mr 37 kDa: a multifunctional inflammatory protein. Chinese medical journal. 2001; 114 : 9-13

    29. Polikandritou Lambros M, Sheu E, Lin J S, Pereira H A. Interaction of a synthetic peptide based on the neutrophil-derived antimicrobial protein CAP37 with dipalmitoyl-phosphatidylcholine membranes. Biochimica et biophysica acta. 1997; 1329 : 285-90

    30. Brackett D J, Lerner M R, Lacquement M A, He R, Pereira H A. A synthetic lipopolysaccharide-binding peptide based on the neutrophil-derived protein CAP37 prevents endotoxin-induced responses in conscious rats. Infection and immunity. 1997; 65 : 2803-11

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Grants

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    16. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.

    17. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.

    18. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.

    19. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.

    20. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.

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Awards and Honors

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                                                                                            11. American Heart Association. Established Investigator. Date: 1998.  

                                                                                            12. OUHSC. Provosts' Research Award to Junior Faculty. Date: 1994.  

                                                                                            13. American Lung Association. American Lung Association Research Award. Date: 1990.  

                                                                                            14. Gordon Research Conference on Phagocytes, New Hampshire. Travel Scholarship. Date: 1987.  

                                                                                            15. University of Melbourne, Australia. BSc (Honours) First Class Honours and First Place. Date: 1977.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.