H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

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    36. D'Cruz O J, Pereira H A, Haas, Jr G G. Sperm immobilizing activity of a synthetic bioactive peptide 20-44 of 37-kDa cationic antimicrobial protein (CAP37) of human neutrophils. Journal of andrology. 1995; 16 : 432-40

    37. Pereira H A. CAP37, a neutrophil-derived multifunctional inflammatory mediator. Journal of leukocyte biology. 1995; 57 : 805-12

    38. Pereira H A, Erdem I, Pohl J, Spitznagel J K. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90 : 4733-7

    39. Morgan J G, Sukiennicki T, Pereira H A, Spitznagel J K, Guerra M E, Larrick J W. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. Journal of immunology (Baltimore, Md. : 1950). 1991; 147 : 3210-4

    40. Morgan J G, Pereira H A, Sukiennicki T, Spitznagel J K, Larrick J W. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. Advances in experimental medicine and biology. 1991; 305 : 89-96

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Grants

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    1. Vision Science Training Program. NIH. Start Date: 2021. End Date: 2026.

    2. STTR Phase 1: Multi-target Peptide Drug for Alzheimer's Disease. NIA. Start Date: 2024. End Date: 2025.

    3. STTR Phase 1: Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2023.

    4. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2018. End Date: 2023.

    5. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

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Awards and Honors

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                                                                                            6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.  

                                                                                            7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.  

                                                                                            8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.  

                                                                                            9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.  

                                                                                            10. Department of Pathology. Fred G Silva Research Award. Date: 1999.  

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Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.