Amanda L. Sharpe, Ph.D.
The Sharpe lab is interested in understanding the contribution of neuropeptides such as proopiomelanocortin, neurotensin, and corticotropin releasing factor to addiction, obesity, and age-related cognitive impairment, and in the development of therapeutics to treat these conditions. We use behavioral (operant conditioning), anatomical, pharmacological, and molecular approaches to address our research questions, often in combination with genetic mouse models. We are interested in the normal physiological role for these neuropeptides, as well as the adaptations that occur in this neurocircuitry under the conditions of obesity, food restriction, and chronic drug use. The long-term goals of our lab are to 1) elucidate the pharmacology and neurocircuitry involved in the regulation of appetite for and consumption of rewards (both food and drug), and 2) to determine the contribution of hypothalamic neuropeptides to age-related conditions such as obesity and cognitive decline.
Education & Experience
B.S. in Pharmacy
Ohio Northern University, Ada, OH1997
Ph.D. in Pharmacology
Wake Forest University, Winston-Salem, NC2002
Postdoc in Behavioral Neuroscience
Oregon Health & Science University, Portland, OR2007
Effect of obesity on proopiomelanocortin regulation of reward and feeding
Presbyterian Health Foundation07/01/2018 - 06/30/2019
Effects of dietary restriction on age-related neurophysiological adaptations: From behavior to single dopaminergic neurons
Oklahoma Medical Research Foundation05/01/2018 - 04/30/2021
Publications & Presentations
- Lynch W B, Tschumi C W, Sharpe A, Branch S Y, Chen C, Ge G, Li S, Beckstead M J. Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model. Movement disorders : official journal of the Movement Disorder Society. 2018; 33 : 1928-1937
- Dominguez-Lopez S, Piccart E, Lynch W B, Wollet M B, Sharpe A, Beckstead M J. Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. The international journal of neuropsychopharmacology. 2018; 21 : 361-370
- Logan S, Owen D, Chen S, Chen W J, Ungvari Z, Farley J R, Csiszar A, Sharpe A, Loos M, Koopmans B, Richardson A, Sonntag W E. Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice. GeroScience. 2018; 40 : 123-137
- Dominguez-Lopez S, Piccart E, Lynch W B, Wollet M B, Sharpe A, Beckstead M J. Antagonism of neurotensin receptors in the ventral tegmental area decreases methamphetamine self-administration and methamphetamine seeking in mice. The international journal of neuropsychopharmacology. 2017
- Sharpe A, Varela E, Beckstead M J. Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. PloS one. 2017; 12 : e0180710
- The role of proopiomelanocortin neurons in age-related cognitive decline. 2019.
- Effects of dietary restriction on age-related neurophysiological adaptations: from behavior to single dopaminergic neurons. 2016.
- Effects of obesity on proopiomelanocortin regulation of reward and feeding. 2018.
- The role of dendrodendritic dopamine neurotransmission in methamphetamine abuse. 2013.