Lucila Garcia-Contreras, Ph.D.

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Summary

The research goal of my laboratory is “Targeted Drug Delivery” and involves the rational design of dosage forms and their in vitro evaluation, which are used to design in vivo studies. In turn, the information obtained in in vitro and in vivo studies is used to understand the underlying reasons of the performance of the dosage form with the objective of improving its formulation design to achieve the desired therapeutic effect. 

   A recent project that illustrates this process is the formulation of a novel molecule with anticancer and antimicrobial activity for pulmonary delivery as nanocrystals or microparticles. In vitro evaluation included size analysis using Scanning Electron Microscopy (SEM) and laser diffraction; stability, using (Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). We determined the aerosol performance of these formulations using commercial dry powder inhalers and performed pharmacokinetic studies to determine the disposition of the drug after pulmonary administration to mice. Lastly, in collaboration with Dr. Jie Wu from the OUHSC Department of Pathology, we assessed the efficacy of the nanocrystals in a transgenic mouse model of adenocarcinoma.

   My laboratory also designs dosage forms for oral, vaginal and transdermal administration following same procedure.  A second line of investigation of my laboratory is the development of needle-less vaccines to provide mucosal and systemic immunization. We are interested in elucidating the role of cell mediated immune (CMI) response and humoral immunity to the overall protection provided by the vaccine. Examples of vaccines studied in my laboratory include vaccines against tuberculosis, West Nile Virus, Diphtheria and Shigellosis.

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Publications & Presentations

36. Benbrook D M, Janakiram N B, Chandra V, Pathuri G, Madka V, Stratton N C, Masamha C P, Farnsworth C N, Garcia-Contreras L, Hatipoglu M K, Lighfoot S, Rao C V. Development of a dietary formulation of the SHetA2 chemoprevention drug for mice. Investigational new drugs. 2018; 36 : 561-570

37. Hatipoglu S M, Tsaliki M, Garcia-Contreras L. Inhalable Clofazimine Nanocrystals for Tuberculosis Treatment. Respiratory Drug Delivery 2018. 2018; 3

38. Mahjabeen S, Hatipoglu M K, Chandra V, Benbrook D M, Garcia-Contreras L. Optimization of a Vaginal Suppository Formulation to Deliver SHetA2 as a Novel Treatment for Cervical Dysplasia. Journal of pharmaceutical sciences. 2018; 107 : 638-646

39. Ibrahim M, Hatipoglu M K, Garcia-Contreras L. SHetA2 Dry Powder Aerosols for Tuberculosis: Formulation, Design, and Optimization Using Quality by Design. Molecular pharmaceutics. 2018; 15 : 300-313

40. Benbrook D M, Janakiram N B, Chandra V, Pathuri G, Madka V, Stratton N C, Masamha C P, Farnsworth C N, Garcia-Contreras L, Hatipoglu M K, Lighfoot S, Rao C V. Development of a dietary formulation of the SHetA2 chemoprevention drug for mice. Investigational new drugs. 2017

Grants

11. Inhalable Microparticulate SHetA2 Nanocrystals for Lung Cancer Treatment. State Agency. Start Date: 2016. End Date: 2017.

12. Stable Needleless Vaccine against Shigella spp. NIH. Start Date: 2014. End Date: 2017.

13. Development of SHetA2 vaginal suppositories for treatment of cervical dysplasia. Misc Non-Federal. Start Date: 2015. End Date: 2015.

14. Inhaled SHetA2 (NSC 721689) dry powder aerosols as novel treatment for tuberculosis. Non-federal. Start Date: 2014. End Date: 2015.

15. Development of SHetA2 vaginal suppositories for treatment of cervical dysplasia. Misc Non-Federal. Start Date: 2015. End Date: 2015.

Awards and Honors

1. University of Oklahoma Health Sciences Center. Carlisle and Lurline Mabrey Presidential Professorship. Date: 2020.


2. Respiratory Drug Delivery. Posters on the podium. Date: 2012.


3. Graduate Research Association of Students in Pharmaceutics Best poster presentation. Date: 1997.


4. Fulbright. Fulbright-Conacyt Scholarship. Date: 1993.


5. National Autonomous University of Mexico. Gabino Barreda Medal-UNAM. Date: 1991.

Education

1. Degree: Post doctoral education. the University of North Carolina at Chapel Hill. Date: 2001.


2. Degree: Ph D. The University of Georgia. Date: 1999.


3. Degree: MS. The University of Georgia. Date: 1995.


4. Degree: Chemist Pharmacist Biologist. National Autonomous University of Mexico. Date: 1991.

Administrative Assignments

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