Lucila Garcia-Contreras, Ph.D.

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Summary

The research goal of my laboratory is “Targeted Drug Delivery” and involves the rational design of dosage forms and their in vitro evaluation, which are used to design in vivo studies. In turn, the information obtained in in vitro and in vivo studies is used to understand the underlying reasons of the performance of the dosage form with the objective of improving its formulation design to achieve the desired therapeutic effect. 

   A recent project that illustrates this process is the formulation of a novel molecule with anticancer and antimicrobial activity for pulmonary delivery as nanocrystals or microparticles. In vitro evaluation included size analysis using Scanning Electron Microscopy (SEM) and laser diffraction; stability, using (Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). We determined the aerosol performance of these formulations using commercial dry powder inhalers and performed pharmacokinetic studies to determine the disposition of the drug after pulmonary administration to mice. Lastly, in collaboration with Dr. Jie Wu from the OUHSC Department of Pathology, we assessed the efficacy of the nanocrystals in a transgenic mouse model of adenocarcinoma.

   My laboratory also designs dosage forms for oral, vaginal and transdermal administration following same procedure.  A second line of investigation of my laboratory is the development of needle-less vaccines to provide mucosal and systemic immunization. We are interested in elucidating the role of cell mediated immune (CMI) response and humoral immunity to the overall protection provided by the vaccine. Examples of vaccines studied in my laboratory include vaccines against tuberculosis, West Nile Virus, Diphtheria and Shigellosis.

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Publications & Presentations

171. White C A, Garcia-Contreras L. Influence of gender on the biliary transport of organic anions using cefoperazone as a model compound. American Association of Pharmaceutical Scientists. 2000

172. Garcia-Contreras L, O’Toole D, Smart J, Newcomer C, Hickey A J. Short-term effects of pulmonary insulin and chaperone H-MAP in the lungs. American Association of Pharmaceutical Scientists. 2000

173. Garcia-Contreras L, Kazantseva M, Suarez S, Newcomer C, McMurray D N, Hickey A J. Treatment of primary pulmonary tuberculosis. Use of aerosol infection guinea pig model to evaluate the impact of a single dose aerosolized rifampicin loaded PLGA microspheres at early stages of tuberculosis. ASM Conference in Tuberculosis: Past, present and future. 2000

174. Garcia-Contreras L, White C A. Effect of simulated weightlessness on the active biliary and renal secretion of cefoperazone. American Association of Pharmaceutical Scientists. 1999

175. Garcia-Contreras L, White C A. Influence of food on the chronokinetics of active biliary and renal excretion of ampicillin. Eighth International Conference of Chronopharmacology and Chronotherapeutics / American Association for Medical Chronobiology and Chronotherapeutics. 1999

Grants

11. Inhalable Microparticulate SHetA2 Nanocrystals for Lung Cancer Treatment. State Agency. Start Date: 2016. End Date: 2017.

12. Stable Needleless Vaccine against Shigella spp. NIH. Start Date: 2014. End Date: 2017.

13. Development of SHetA2 vaginal suppositories for treatment of cervical dysplasia. Misc Non-Federal. Start Date: 2015. End Date: 2015.

14. Inhaled SHetA2 (NSC 721689) dry powder aerosols as novel treatment for tuberculosis. Non-federal. Start Date: 2014. End Date: 2015.

15. Development of SHetA2 vaginal suppositories for treatment of cervical dysplasia. Misc Non-Federal. Start Date: 2015. End Date: 2015.

Awards and Honors

1. University of Oklahoma Health Sciences Center. Carlisle and Lurline Mabrey Presidential Professorship. Date: 2020.


2. Respiratory Drug Delivery. Posters on the podium. Date: 2012.


3. Graduate Research Association of Students in Pharmaceutics Best poster presentation. Date: 1997.


4. Fulbright. Fulbright-Conacyt Scholarship. Date: 1993.


5. Diario de México. Diario de México Medal. Date: 1991.

Education

1. Degree: Post doctoral education. the University of North Carolina at Chapel Hill. Date: 2001.


2. Degree: Ph D. The University of Georgia. Date: 1999.


3. Degree: MS. The University of Georgia. Date: 1995.


4. Degree: Chemist Pharmacist Biologist. National Autonomous University of Mexico. Date: 1991.

Administrative Assignments

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