H. Anne Pereira, Ph.D.

David L. Boren Professor/Dean, Graduate College

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu


Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira



Publications & Presentations

<< 1 2 3 4 5 6 7 > >>
    16. Kasus-Jacobi A, Noor-Mohammadi S, Griffith G L, Hinsley H, Mathias L, Pereira A. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties. Journal of leukocyte biology. 2015; 97 : 341-50

    17. Kasus-Jacobi A, Nag O, Awasthi V, Babizhayev M, Pereira A. Investivating carcinine transport and the expression profile of transporter genes in human corneal epithelial cells. Springer. 2015

    18. Griffith G L, Kasus-Jacobi A, Lerner M R, Pereira A. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCδ). Investigative ophthalmology & visual science. 2014; 55 : 4886-95

    19. Griffith G L, Russell R A, Kasus-Jacobi A, Pereira A. CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. IOVS. 2013

    20. Pereira H A, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen T T, Pohl J, Wozniak K, Fidel P L. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Medical mycology. 2010; 48 : 263-72

<< 1 2 3 4 5 6 7 > >>



Grants

<< 1 2 3 4 5 >>
    6. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.

    7. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.

    8. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

    9. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.

    10. Oklahoma COBRE in Structural Biology – Phase II. NIH. Start Date: 2017. End Date: 2019.

<< 1 2 3 4 5 >>



Awards and Honors

<< 1 2 3 4 >>
                                                                                            6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.  

                                                                                            7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.  

                                                                                            8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.  

                                                                                            9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.  

                                                                                            10. Department of Pathology. Fred G Silva Research Award. Date: 1999.  

<< 1 2 3 4 >>



Education

                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.