H. Anne Pereira, Ph.D.

Dean, Graduate College and David L. Boren Professor

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu

Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.


Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira


Publications & Presentations

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    6. Griffith G L, Kasus-Jacobi A, Pereira A. Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections. Advances in wound care. 2017; 6 : 175-190

    7. Kasus-Jacobi A, Griffith G L, Lerner M, Pereira A. Effect of Cationic Antimicrobial Protein CAP37 on Cytokine Profile during Corneal Wound Healing. Journal of ocular diseases and therapeutics. 2017; 5 : 19-27

    8. Makoni M, Eckert J, Pereira H A, Nizet V, Lawrence S M. Alterations in neonatal function attributable to increased immature forms. Early Human Development. 2016

    9. Casanegra A, Stoner J A, Tafur A J, Pereira H A, Rathbun S W, Gardner A W. Differences in galectin-3, a biomarker of fibrosis, between participants with peripheral arterial disease and participants with normal ankle-brachial index. Vascular Medicine. 2016

    10. Stock A J, Kasus-Jacobi A, Wren J, Sjoelund V, Prestwich G, Pereira H A. The role of neutrophil proteins on the amyloid beta-RAGE axis. Plos One. 2016

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Grants

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    1. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2023. End Date: 2028.

    2. Vision Science Training Program. NIH. Start Date: 2021. End Date: 2026.

    3. STTR Phase 1: Multi-target Peptide Drug for Alzheimer's Disease. NIA. Start Date: 2024. End Date: 2025.

    4. STTR Phase 1: Novel Ophthalmic Product for Corneal Infections and Injuries. NIH. Start Date: 2021. End Date: 2023.

    5. Oklahoma Shared Clinical and Translational Resources. NIH. Start Date: 2018. End Date: 2023.

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Awards and Honors

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                                                                                            16. Commonwealth of Australia. Commonwealth Postgraduate Research Award. Date: 1977.  

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Education
 
                               
                                                            
                        
                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.  




                        		 
                                                                                  
                        
                                                                               
 
                   
 
                
     
                
                 	                                        
                    
                                            	                           
                                                
                                                                                                                                                                               
Administrative Assignments

                                  
                                                           
                        
                                                
     1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
                                                
     2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.