H. Anne Pereira, Ph.D.

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Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

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Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

Patents

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Publications & Presentations

26. Ruan X, Chodosh J, Callegan M C, Booth M C, Lee T D, Kumar P, Gilmore M S, Pereira H A. Corneal expression of the inflammatory mediator CAP37. Investigative ophthalmology & visual science. 2002; 43 : 1414-21

27. Lee T D, Gonzalez M L, Kumar P, Chary-Reddy S, Grammas P, Pereira H A. CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions. The American journal of pathology. 2002; 160 : 841-8

28. Pereira H A. Cationic antimicrobial protein of Mr 37 kDa: a multifunctional inflammatory protein. Chinese medical journal. 2001; 114 : 9-13

29. Polikandritou Lambros M, Sheu E, Lin J S, Pereira H A. Interaction of a synthetic peptide based on the neutrophil-derived antimicrobial protein CAP37 with dipalmitoyl-phosphatidylcholine membranes. Biochimica et biophysica acta. 1997; 1329 : 285-90

30. Brackett D J, Lerner M R, Lacquement M A, He R, Pereira H A. A synthetic lipopolysaccharide-binding peptide based on the neutrophil-derived protein CAP37 prevents endotoxin-induced responses in conscious rats. Infection and immunity. 1997; 65 : 2803-11

Grants

6. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

7. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.

8. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.

9. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

10. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.

Awards and Honors

1. University of Oklahoma Health Sciences Center. David L Boren Professorship. Date: 2018.


2. College of Pharmacy. Herbert and Dorothy Langsam Chair. Date: 2018.


3. Oklahoma BioScience Association. OK Bio Researcher Recognition Award -Winner. Date: 2016.


4. Journal Record. Journal Record Innovator of the Year. Date: 2016.


5. National Academy of Inventors. Fellow. Date: 2015.

Education

1. Degree: Ph D. University of Melbourne. Date: 1982.


2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.


3. Degree: BS. University of Melbourne. Date: 1975.

Administrative Assignments

1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
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2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.
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