1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
H. Anne Pereira, Ph.D.
Dean, Graduate College and David L. Boren Professor
Pharmaceutical Sciences
Phone (405) 271-6593 x58034
Fax (405) 271-7505
Office CPB 329
Email anne-pereira@ouhsc.edu
Summary
My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Research
This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.
Patents
Biomarker and method for detecting a chronic inflammatory-associated disease
Patent No. 8,450,071
USA
H. Anne Pereira
Publications & Presentations
- 16. Kasus-Jacobi A, Nag O, Awasthi V, Babizhayev M, Pereira A. Investivating carcinine transport and the expression profile of transporter genes in human corneal epithelial cells. Springer. 2015
17. Griffith G L, Kasus-Jacobi A, Lerner M R, Pereira A. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCĪ“). Investigative ophthalmology & visual science. 2014; 55 : 4886-95
18. Griffith G L, Russell R A, Kasus-Jacobi A, Pereira A. CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. IOVS. 2013
19. Pereira H A, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen T T, Pohl J, Wozniak K, Fidel P L. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Medical mycology. 2010; 48 : 263-72
20. Gordon Y J, Romanowski E G, Shanks R M, Yates K A, Hinsley H, Pereira H A. CAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1. Current eye research. 2009; 34 : 241-9
Grants
- 6. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.
7. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.
8. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.
9. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.
10. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.
Awards and Honors
- 16. Commonwealth of Australia. Commonwealth Postgraduate Research Award. Date: 1977.
Education
- 1. Degree: Ph D. University of Melbourne. Date: 1982.
2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.
3. Degree: BS. University of Melbourne. Date: 1975.
Administrative Assignments
2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.