H. Anne Pereira, Ph.D.

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Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

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Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.

Patents

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Publications & Presentations

16. Kasus-Jacobi A, Nag O, Awasthi V, Babizhayev M, Pereira A. Investivating carcinine transport and the expression profile of transporter genes in human corneal epithelial cells. Springer. 2015

17. Griffith G L, Kasus-Jacobi A, Lerner M R, Pereira A. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCδ). Investigative ophthalmology & visual science. 2014; 55 : 4886-95

18. Griffith G L, Russell R A, Kasus-Jacobi A, Pereira A. CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. IOVS. 2013

19. Pereira H A, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen T T, Pohl J, Wozniak K, Fidel P L. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Medical mycology. 2010; 48 : 263-72

20. Gordon Y J, Romanowski E G, Shanks R M, Yates K A, Hinsley H, Pereira H A. CAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1. Current eye research. 2009; 34 : 241-9

Grants

6. Molecular Basis of Immunity. NIH. Start Date: 2018. End Date: 2023.

7. OU Entrepreneurship Roadmap. Misc Federal. Start Date: 2021. End Date: 2022.

8. OSCTR Community Engaged Research Exploratory Award. NIH. Start Date: 2021. End Date: 2022.

9. Development of Bioactive Peptides for the Inhibition of Neuroinflammation and Neurotoxicity Induced by Amyloid-beta. Non-federal. Start Date: 2020. End Date: 2021.

10. Novel Peptide Therapeutic for Corneal Wound Healing and Infections. Misc Non-Federal. Start Date: 2019. End Date: 2020.

Awards and Honors

6. American Association for the Advancement of Sciences (AAAS)Fellow. Date: 2014.


7. OUHSC. Henry Zarrow Presidential Professorship. Date: 2008.


8. Grace & Franklin Bernsen Foundation. Finalist, Grace & Franklin Bernsen Foundation Most Promising New Business Award. Date: 2007.


9. The Journal Record. On the Brink, Award for Innovation. Date: 2006.


10. Department of Pathology. Fred G Silva Research Award. Date: 1999.

Education

1. Degree: Ph D. University of Melbourne. Date: 1982.


2. Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.


3. Degree: BS. University of Melbourne. Date: 1975.

Administrative Assignments

1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
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2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.
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