H. Anne Pereira, Ph.D.

Dean, Graduate College and David L. Boren Professor

Pharmaceutical Sciences

Phone (405) 271-6593 x58034

Fax (405) 271-7505

Office CPB 329

Email anne-pereira@ouhsc.edu

Summary

My laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.


Research

This laboratory investigates the role of a novel inflammatory mediator known as CAP37. We focus on the significance of this protein in host defense against severe infections including infections of the eye and in various inflammatory mediated diseases such as atherosclerosis and Alzheimer's disease. We currently employ a combination of cellular, immunological, biochemical and molecular approaches at the in vitro and in vivo level to solve these questions. Our long-term goals are to design new and effective antibiotics and anti-inflammatory therapeutics.



Patents

Biomarker and method for detecting a chronic inflammatory-associated disease

Patent No. 8,450,071

USA

H. Anne Pereira


Publications & Presentations

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    11. Silasi-Mansat R, Zhu H, Georgescu C, Popescu N, Keshari R S, Peer G, Lupu C, Taylor F B, Pereira H A, Kinasewitz G, Lambros J D, Lupu F. Complement inhibition decreases early fibrogenic events in the lung of septic baboons. Journal of cellular and molecular medicine. 2015; 19 : 2549-63

    12. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira H A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. 2015; 144 : 293-308

    13. Brock A J, Kasus-Jacobi A, Lerner M, Logan S, Adesina A M, Pereira A. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. Histochemistry and cell biology. 2015; 144 : 293-308

    14. Lawrence S M, Eckert J, Makoni M, Pereira H A. Is the Use of Complete Blood Counts with Manual Differentials an Antiquated Method of Determining Neutrophil Composition in Newborns?. Annals of clinical and laboratory science. 2015; 45 : 403-13

    15. Kasus-Jacobi A, Noor-Mohammadi S, Griffith G L, Hinsley H, Mathias L, Pereira A. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties. Journal of leukocyte biology. 2015; 97 : 341-50

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Grants

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    16. 49th Annual Meeting of the Society for Leukocyte Biology - Inflammation, Immunity and Cancer: Neutrophils and Other leukocytes. NIH. Start Date: 2016. End Date: 2017.

    17. Molecular Basis of Immunity. NIH. Start Date: 2012. End Date: 2017.

    18. Novel topical peptide therapeutic for the treatment of wounds infected with antibiotic resistant Gram negative bacteria. Non-federal. Start Date: 2016. End Date: 2017.

    19. Wound healing mechanisms modulated by novel antimicrobial peptide. Misc Non-Federal. Start Date: 2015. End Date: 2016.

    20. 48th Annual Meeting of the Society for leukocyte Biology - Immunity in Health and Disease. NIH. Start Date: 2015. End Date: 2016.

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Awards and Honors

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                                                                                            16. Commonwealth of Australia. Commonwealth Postgraduate Research Award. Date: 1977.  

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Education
 
                               
                                                            
                        
                                                                                            1.  Degree: Ph D. University of Melbourne. Date: 1982.  

                                                                                            2.  Degree: BSc (Honours) First class honours & First Place. University of Melbourne. Date: 1976.  

                                                                                            3.  Degree: BS. University of Melbourne. Date: 1975.  




                        		 
                                                                                  
                        
                                                                               
 
                   
 
                
     
                
                 	                                        
                    
                                            	                           
                                                
                                                                                                                                                                               
Administrative Assignments

                                  
                                                           
                        
                                                
     1. Role: Dean. Scope: University. Description: Dean of the Graduate College. Responsible for Graduate Programs on the Health Sciences Campus and the Postdoctoral Office. Date: 2014.
                                                
     2. Role: Associate Dean. Scope: College. Description: Responsible for Oversight of research activities in the College of Pharmacy, mentoring junior faculty and trainees. Date: 2009.